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Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy

  • Chapter
Protein-Protein Interactions as New Drug Targets

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 186))

Abstract

There is increasing awareness that processes, such as development, aging and cancer, are governed, to a considerable extent, by epigenetic processes, such as DNA and histone modifications. The sites of these modifications in turn reflect their position and role in the nuclear architecture. Since epigenetic changes are easier to reverse than mutations, drugs that remove or add the chemical tags are at the forefront of research for the treatment of cancerous and inflammatory diseases. This review will use selected examples to develop a unified view that might assist the systematic development of novel therapeutic regimens.

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Authors and Affiliations

  1. Helmholtz-Zentrum für Infektionsforschung MBIO/Epigenetic Regulation, Inhoffenstraße 7, 38124, Braunschweig, Germany

    A. Gluch & J. Bode

  2. Molecular Biology Laboratory, Institute for Biological Research, 11060, Belgrade, Serbia

    M. Vidakovic

Authors
  1. A. Gluch
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  2. M. Vidakovic
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  3. J. Bode
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Editor information

Editors and Affiliations

  1. Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany

    Enno Klussmann

  2. The Vollum Institute, Oregon Health & Science University, Medical Research Bldg, Rm 322D 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    John Scott Ph.D.

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© 2008 Springer-Verlag Berlin Heidelberg

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Gluch, A., Vidakovic, M., Bode, J. (2008). Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy. In: Klussmann, E., Scott, J. (eds) Protein-Protein Interactions as New Drug Targets. Handbook of Experimental Pharmacology, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72843-6_4

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