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Table of contents (20 chapters)
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Front Matter
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Organization of Scaffolds
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Scaffolding Proteins and Cellular Signalling
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Interference with Protein-Protein Interaction Sites as a New Pharmacological Concept
About this book
Disease-relevant intracellular protein-protein interactions occurring at defined cellular sites possess great potential as drug targets. They permit highly specific pharmacological interference with defined cellular functions. Drugs targeting such interactions are likely to act with fewer side effects than conventional medication influencing whole cell functions.
This book discusses therapeutically relevant protein-protein interactions with a major focus on scaffolding proteins tethering signal transduction processes to defined cellular compartments by direct protein-protein interactions. Recent advances in the development of pharmacological agents interfering with protein-protein interactions are highlighted.
Editors and Affiliations
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Leibniz-Institut für Molekulare Pharmakologie, Berlin, Germany
Enno Klussmann
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The Vollum Institute, Oregon Health & Science University, Portland, USA
John Scott
Bibliographic Information
Book Title: Protein-Protein Interactions as New Drug Targets
Editors: Enno Klussmann, John Scott
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-540-72843-6
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2008
Hardcover ISBN: 978-3-540-72842-9Published: 23 June 2008
Softcover ISBN: 978-3-642-09194-0Published: 19 October 2010
eBook ISBN: 978-3-540-72843-6Published: 20 May 2008
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XV, 512
Topics: Pharmacology/Toxicology, Cell Biology, Medical Biochemistry, Molecular Medicine
Industry Sectors: Biotechnology, Chemical Manufacturing, Consumer Packaged Goods, Health & Hospitals, Pharma