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Scaffolding Proteins in Cardiac Myocytes

  • Chapter
Protein-Protein Interactions as New Drug Targets

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 186))

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Abstract

Post-translational modification, such as protein phosphorylation, plays a critical role to reversibly amplify and modulate signaling pathways. Since kinases and phosphatases have broad substrate recognition motifs, compartmentalization and localization of signaling complexes are required to achieve specific signals. Scaffolds are proteins that associate with two or more binding partners and function to enhance the efficiency and/or specificity of cellular signaling pathways. The identification of scaffolding proteins that control the tempo and/or spatial organization of signaling pathways in cells has benefited enormously from recent technological advances that allow for the detection of protein-protein interactions, including in vivo in intact cells. This review will focus on scaffolding proteins that nucleate multi-protein complexes (and could represent novel entry points into signaling pathways that might be amenable to therapeutic manipulation) in cardiomyocytes.

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, 10032, USA

    N. L. Chudasama & S. O. Marx

  2. Departments of Pharmacology, College of Physicians and Surgeons, Columbia University, 630 West, 168 Street, New York, NY, 10032, USA

    S. F. Steinberg

Authors
  1. N. L. Chudasama
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  2. S. O. Marx
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  3. S. F. Steinberg
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Editor information

Editors and Affiliations

  1. Leibniz-Institut für Molekulare Pharmakologie, Robert-Rössle-Str. 10, 13125, Berlin, Germany

    Enno Klussmann

  2. The Vollum Institute, Oregon Health & Science University, Medical Research Bldg, Rm 322D 3181 SW Sam Jackson Park Road, Portland, OR, 97239-3098, USA

    John Scott Ph.D.

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© 2008 Springer-Verlag Berlin Heidelberg

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Chudasama, N.L., Marx, S.O., Steinberg, S.F. (2008). Scaffolding Proteins in Cardiac Myocytes. In: Klussmann, E., Scott, J. (eds) Protein-Protein Interactions as New Drug Targets. Handbook of Experimental Pharmacology, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72843-6_13

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