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Lung Dendritic Cells: Targets for Therapy in Allergic Disease

  • Chapter
Dendritic Cells

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 188))

Abstract

Dendritic cells (DCs) are crucial in determining the functional outcome of allergen encounter in the lung. Antigen presentation by myeloid DCs leads to Th2 sensitization typical of allergic disease, whereas antigen presentation by plas-macytoid DCs serves to dampen inflammation. It is increasingly clear that DCs have an antigen presenting function beyond sensitisation. DCs therefore constitute a novel target for the development of antiallergic therapy aimed at the origin of the inflammatory cascade. A careful study of DC biology and of the receptors expressed by lung DCs has provided a framework for the discovery of novel antiallergic compounds.

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Authors and Affiliations

  1. Department of Pulmonary Medicine, Erasmus M.C. Dr. Molerwaterplein, Rotterdam, GE, 50, 3015, The Netherlands

    Bart N. Lambrecht & Hamida Hammad

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  1. Bart N. Lambrecht
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  2. Hamida Hammad
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Correspondence to Bart N. Lambrecht .

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Editors and Affiliations

  1. DIIID, King's College, London School of Medicine, Guy's Hospital, London, UK

    Giovanna Lombardi (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation) (Professor of Human Transplant Immunology MRC Centre in Transplantation Dep. of Nephrology and Transplantation)

  2. 5th Floor Hodgkin Building, School of Biomedical and Health Sciences, King's College London, London, SE1 1UL, United Kingdom

    Yanira Riffo-Vasquez (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division) (Research Fellow The Sackler Institute of Pulmonary Pharmacology Pharmaceutical Science Division)

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Lambrecht, B.N., Hammad, H. (2009). Lung Dendritic Cells: Targets for Therapy in Allergic Disease. In: Lombardi, G., Riffo-Vasquez, Y. (eds) Dendritic Cells. Handbook of Experimental Pharmacology, vol 188. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-71029-5_5

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