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Dendritic Cells

  • Giovanna Lombardi
  • Yanira Riffo-Vasquez

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 188)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Biology of Dendritic Cells

    1. Alfonso Martín-Fontecha, Antonio Lanzavecchia, Federica Sallusto
      Pages 31-49
    2. Gabrielle Belz, Adele Mount, Frederick Masson
      Pages 51-77
  3. Role of Dendritic Cells in Disease

    1. M. H. Wenink, W. Han, R. E. M. Toes, T. R. D. J. Radstake
      Pages 81-98
    2. Bart N. Lambrecht, Hamida Hammad
      Pages 99-114
    3. Alex KleinJan, Bart N. Lambrecht
      Pages 115-136
    4. Maria Dolores Ramírez-González, Miguel Herrera-Enríquez, Luisa Geraldine Villanueva-Rodríguez, Andres Eliu Castell-Rodríguez
      Pages 137-162
  4. Manipulation of Dendritic Cells for Immunotherapy

    1. Matthew Buckland, Giovanna Lombardi
      Pages 197-213
    2. Ryan Fischer, Heth R. Turnquist, Timuçin Taner, Angus W. Thomson
      Pages 215-232
    3. Cees van Kooten, Annelein S. Stax, Andrea M. Woltman, Kyra A. Gelderman
      Pages 233-249
    4. Luciano Adorini, Giuseppe Penna
      Pages 251-273
    5. Steven Patterson, Timos Papagatsias, Adel Benlahrech
      Pages 275-293
    6. Stefano Maria Santini, Caterina Lapenta, Laura Santodonato, Giuseppina D'Agostino, Filippo Belardelli, Maria Ferrantini
      Pages 295-317
    7. A. A. van de Loosdrecht, W. van den Ancker, I. Houtenbos, G. J. Ossenkoppele, T. M. Westers
      Pages 319-348
  5. Back Matter
    Pages 349-353

About this book

Introduction

The understanding of the role of dendritic cells (DCs) in immune responses has come a long way since Steinmann and colleagues described these cells in 1972. - tensive research during the intervening period has provided a good understanding of the complexity of the DC system and its pivotal role in immunity. It is also now clearer how different subsets of DCs interact and regulate each other and how DC populations affect the function of other cells of the immune system. The improved understanding of their role in immune response has led to the idea that modulation of DC functions by, for example, pharmacological agents could be used as a pot- tial therapeutic approach in some pathological conditions. The actual applicability and therapeutic potential of all these approaches is yet to be fully demonstrated but nonetheless, animal models of human diseases are proving to be very helpful in the evaluation of manipulated DCs as a new treatment in diseases like cancer, auto- munity or asthma. DCs are integral to the initiation and regulation of immune response (Banchereau et al. 2000). The outcome of antigen presentation by DCs is determined by their maturation status, which can be induced by their interaction with danger signals. To recognise a wide array of pathogen-associated molecular patterns (PAMP), DCs express a number of pattern recognition receptors (PRR) such as Toll-like rec- tors (TLRs) and C-type lectin receptors (CLR) that recognise structural components of pathogens and discriminate between self and non-self molecules.

Keywords

Dendritic Cells HIV Human Diseases Immunotherapy Migration Tolerance Transplantation Viral Immunity infections

Editors and affiliations

  • Giovanna Lombardi
    • 1
  • Yanira Riffo-Vasquez
    • 2
  1. 1.DIIIDKing's College, London School of Medicine, Guy's HospitalLondonUK
  2. 2.5th Floor Hodgkin Building, School of Biomedical and Health SciencesKing's College LondonLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-71029-5
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-71028-8
  • Online ISBN 978-3-540-71029-5
  • Series Print ISSN 0171-2004
  • Buy this book on publisher's site
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