5.5 Conclusions
Generator function and the purity of 99mTc eluates of the available fission 99Mo generators in Europe have been investigated by several European research institutions over the years. Much information on the benefits of improved technology has been documented, testifying to high standards of manufacturing and to the reliability of validation processes implemented by the regulatory agencies for safe application of the 99Mo/99mTc generator in nuclear medicine.
Several European centers were engaged in implementing GMP standards for the preparation of 99mTc radiopharmaceuticals in nuclear medicine, and thus have contributed to establish a protocol for analytical procedures, which can validate the performance of generator systems from different manufacturers and assure the quality of short-lived generator eluates. The protocol is presented in Appendix Al of this chapter.
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Zolle, I. (2007). Performance and Quality Control of the 99Mo/99mTc Generator. In: Zolle, I. (eds) Technetium-99m Pharmaceuticals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33990-8_5
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