Pain pp 185-188 | Cite as

Skin Punch Biopsy

  • Vinayak Nadar
  • Ratan K. BanikEmail author


Painful neuropathy states involving small peripheral nerve fibers are difficult to diagnose on clinical evaluation. Advances in immunohistochemical staining and use of confocal microscopy have led to the development of skin biopsy techniques for the evaluation of painful neuropathies. In this method, vertical sections of small skin biopsies are obtained and immunolabeled to show nerve endings. This technique provides no information about motor or large myelinated sensory fibers. The technique is minimally invasive and can be repeated to monitor progression of the disease.


Epidermal nerve fibers Skin punch biopsy Immunohistochemistry Small fiber peripheral neuropathy PGP 9.5 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Anesthesiology, University of MinnesotaMinneapolisUSA

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