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Genomic Applications in Pancreatic and Gastric Tumors

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Genomic Applications in Pathology

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Abstract

Next-generation sequencing has expanded our understanding of the molecular alterations that occur in tumors of the pancreas and stomach, and it is now becoming clear that new histologic and molecular-based classification systems are possible. These systems do not replace, but instead complement, the morphologic classification systems that have been developed and tested by pathologists over many decades. Importantly, new classification systems integrate morphology and molecular findings into cohesive systems with significant prognostic and therapeutic implications.

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Conflict of Interest

Ralph Hruban receives royalty payments from Myriad Genetics for the PALB2 invention.

Fátima Carneiro has no conflicts of interest.

Author information

Authors and Affiliations

  1. Ipatimup/i3S, Faculty of Medicine of the University of Porto and Centro Hospitalar São João, Porto, Portugal

    Fátima Carneiro

  2. The Sol Goldman Pancreatic Cancer Research Center, Departments of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Ralph H. Hruban

Authors
  1. Fátima Carneiro
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  2. Ralph H. Hruban
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Correspondence to Ralph H. Hruban .

Editor information

Editors and Affiliations

  1. Professor and Chair of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA

    George Jabboure Netto

  2. Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Clinical Professor of Pathology, University of Chicago Pritzker School of Medicine, Evanston, IL, USA

    Karen L. Kaul

Glossary

MLH1

MUT L homologue 1

MSH

MUT S homologue

MSI-H

High-grade microsatellite instability

TERT

Telomerase RT component

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Carneiro, F., Hruban, R.H. (2019). Genomic Applications in Pancreatic and Gastric Tumors. In: Netto, G., Kaul, K. (eds) Genomic Applications in Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-96830-8_29

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  • DOI: https://doi.org/10.1007/978-3-319-96830-8_29

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