Abstract
Over the last 5 years, major biomedical, technological, and manufacturing advances have helped reshape the therapeutic potential of gene therapies and facilitate their translation to clinical care. This chapter aims to provide brief insights on some of the innovations that are impacting the field, the CRISPR/Cas9 system and the therapeutic use of micro-RNAs are worth mentioning.
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References
McNutt M. Breakthrough to genome editing. Science. 2015;350(6267):1445. https://doi.org/10.1126/science.aae0479.
Pineda M, Moghadam F, Ebrahimkhani MR, Kiani S. Engineered CRISPR systems for next generation gene therapies. ACS Synth Biol. 2017;6(9):1614–26. https://doi.org/10.1021/acssynbio.7b00011.
Wang HX, Li M, Lee CM, et al. CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery. Chem Rev. 2017;117(15):9874–906. https://doi.org/10.1021/acs.chemrev.6b00799.
Puga Yung GL, Rieben R, Bühler L, Schuurman H-J, Seebach J. Xenotransplantation: where do we stand in 2016? Swiss Med Wkly. 2017;147(506):w14403. https://doi.org/10.4414/smw.2017.14403.
Feng W, Dai Y, Mou L, Cooper D, Shi D, Cai Z. The potential of the combination of CRISPR/Cas9 and pluripotent stem cells to provide human organs from chimaeric pigs. Int J Mol Sci. 2015;16(3):6545–56. https://doi.org/10.3390/ijms16036545.
Butler JR, Wang Z-Y, Martens GR, et al. Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response. Transpl Immunol. 2016;35:47–51. https://doi.org/10.1016/j.trim.2016.02.001.
Duncan KM, Mukherjee K, Cornell RA, Liao EC. Zebrafish models of orofacial clefts. Dev Dyn. 2017;246(11):897–914. https://doi.org/10.1002/dvdy.24566.
Hainzl S, Peking P, Kocher T, et al. COL7A1 editing via CRISPR/Cas9 in recessive dystrophic epidermolysis bullosa. Mol Ther. 2017;25(11):2573–84. https://doi.org/10.1016/j.ymthe.2017.07.005.
Mofazzal Jahromi MA, Sahandi Zangabad P, Moosavi Basri SM, et al. Nanomedicine and advanced technologies for burns: preventing infection and facilitating wound healing. Adv Drug Deliv Rev. 2018;123:33–64. https://doi.org/10.1016/j.addr.2017.08.001.
Meng Z, Zhou D, Gao Y, Zeng M, Wang W. miRNA delivery for skin wound healing. Adv Drug Deliv Rev. 2017. https://doi.org/10.1016/j.addr.2017.12.011.
Santulli G. microRNA: medical evidence, Advances in experimental medicine and biology, vol. 888. Cham: Springer; 2015. https://doi.org/10.1007/978-3-319-22671-2.
Wu YF, Mao WF, Zhou YL, Wang XT, Liu PY, Tang JB. Adeno-associated virus-2-mediated TGF-β1 microRNA transfection inhibits adhesion formation after digital flexor tendon injury. Gene Ther. 2016;23(2):167–75. https://doi.org/10.1038/gt.2015.97.
Icli B, Nabzdyk CS, Lujan-Hernandez J, et al. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a. J Mol Cell Cardiol. 2016;91:151–9. https://doi.org/10.1016/j.yjmcc.2016.01.007.
Chang K-P, Lee H-C, Huang S-H, Lee S-S, Lai C-S, Lin S-D. MicroRNA signatures in ischemia-reperfusion injury. Ann Plast Surg. 2012;69(6):668–71. https://doi.org/10.1097/SAP.0b013e3182742c45.
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Giatsidis, G. (2018). Future Directions in Reconstructive and Regenerative Surgery. In: Giatsidis, G. (eds) Gene Therapy in Reconstructive and Regenerative Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-78957-6_9
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