Editors:
Offers a practical overview of the latest research discoveries and clinical trials in the field of gene therapy
Written by prominent surgeons
Also includes a chapter on how to develop gene therapy clinical trials
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Table of contents (9 chapters)
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Front Matter
About this book
Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided.
Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants.
Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
Editors and Affiliations
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Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA
Giorgio Giatsidis
About the editor
Since 2013, he has been conducting research on tissue engineering and regeneration in the Division of Plastic Surgery of Brigham and Women’s Hospital and at Harvard Medical School (Boston, USA), joining the faculty of both Institutions later in 2015. He also holds collaborative appointments at the Boston Children`s Hospital (Boston, USA) and the San Raffaele Hospital (Milan, Italy).
Dr. Giatsidis has several roles in scientific societies and an ad hoc reviewer for multiple scientific journals in the field. His research has been funded by federal sources (the U.S. Department of Defense) and private foundations. Currently, he is a national delegate for Italy in the Research Council of the European Association of Plastic Surgeons (EURAS).
Bibliographic Information
Book Title: Gene Therapy in Reconstructive and Regenerative Surgery
Editors: Giorgio Giatsidis
DOI: https://doi.org/10.1007/978-3-319-78957-6
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-78956-9Published: 27 August 2018
Softcover ISBN: 978-3-030-07689-4Published: 29 December 2018
eBook ISBN: 978-3-319-78957-6Published: 02 August 2018
Edition Number: 1
Number of Pages: VII, 113
Number of Illustrations: 1 b/w illustrations, 7 illustrations in colour
Topics: Plastic Surgery, Regenerative Medicine/Tissue Engineering
Industry Sectors: Health & Hospitals, Pharma