Abstract
The influence of exposure to electric and magnetic fields in pancreatic islets are still scarce and controversial, and it is difficult to conduct a comparison of existing studies due to the different research methods employed. Here, computational simulations were used to study the burst patterns in pancreatic beta cell exposure to constant voltage pulses. Results show that burst patterns in pancreatic beta cells are dependent on the applied voltage and that some voltages may even inhibit this phenomenon. There are critical voltages, such as 2.16 mV, in which the burst change from a medium oscillation to a slow oscillation phase or 3.5 mV that induces transition in the burst from slow to fast oscillation phase. Voltage pulse higher than 3.5 mV leads to the extinction of bursts and, therefore, inhibits the process of insulin secretion. These results are reforced by phase plane analysis.
Highlights
• Computational simulations were used to study the pattern of the burst in pancreatic beta cells in response to constant voltage pulses.
• Stimulation with low amplitude voltage pulses leads to changes in the pattern of the burst in pancreatic beta cells.
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González, R.E.R., da Silva, J.R.F., Albuquerque Nogueira, R. (2018). Effects of External Voltage in the Dynamics of Pancreatic β-Cells: Implications for the Treatment of Diabetes. In: Rojas, I., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2018. Lecture Notes in Computer Science(), vol 10813. Springer, Cham. https://doi.org/10.1007/978-3-319-78723-7_5
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