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References
Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS et al (2003) Developmental pharmacology: drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167
Alcorn J, McNamara PJ (2002) Ontogeny of hepatic and renal systemic clearance pathways in infants: part I. Clin Pharmacokinet 41:959–998
Alcorn J, McNamara PJ (2002) Ontogeny of hepatic and renal systemic clearance pathways in infants: part II. Clin Pharmacokinet 41:1077–1094
Gibaldi M (1984) Gastrointestinal absorption: physicochemical considerations. In: Biopharmaceutics and clinical pharmacokinetics, 3rd edn. Lea and Febiger, Philadelphia, pp 44–63
Huang NN, High RH (1953) Comparison of serum levels following the administration of oral and parenteral preparations of penicillin to infants and children of various age groups. J Pediatr 42:657–668
Linday L, Dobkin JF, Wang TC, Butler VP Jr, Saha JR et al (1987) Digoxin inactivation by the gut flora in infancy and childhood. Pediatrics 79:544–548
Loebstein R, Koren G (1998) Clinical pharmacology and therapeutic drug monitoring in neonates and children. Pediatr Rev 19:423–428
McClean P, Weaver LT (1993) Ontogeny of human pancreatic exocrine function. Arch Dis Child 68:62–65
Alcorn J, McNamara PJ (2003) Pharmacokinetics in the newborn. Adv Drug Del Rev 55:667–686
Johnson TN, Tanner MS, Christopher J, Taylor CJ, Tucker GT (2001) Enterocytic CYP3A4 in a pediatric population: developmental changes and the effect of coeliac disease and cystic fibrosis. Br J Clin Pharmacol 51:451–460
Stahlberg MR, Hietanen E, Maki M (1988) Mucosal biotransformation rates in the small intestine of children. Gut 29:1058–1063
Gibbs JP, Liacouras CA, Baldassano RN, Slattery JT (1999) Up-regulation of glutathione S-transferase activity in enterocytes of young children. Drug Metab Dispos 27:1466–1469
Yaffe SJ, Juchau MR (1974) Perinatal pharmacology. Annu Rev Pharmacol 14:219–238
Fluhr JW, Pfisterer S, Gloor M (2000) Direct comparison of skin physiology in children and adults with bioengineering methods. Pediatr Dermatol 17:436–439
Okah FA, Wickett RR, Pickens WL, Hoath SB (1995) Surface electrical capacitance as a noninvasive bedside measure of epidermal barrier maturation in the newborn infant. Pediatrics 96:688–692
Rutter N (1987) Percutaneous drug absorption in the newborn: hazards and uses. Clin Perinatol 14:911–930
Amato M, Huppi P, Isenschmid M, Schneider H (1992) Developmental aspects of percutaneous caffeine absorption in premature infants. Am J Perinatol 9:431–434
West DP, Worobec S, Solomon LM (1981) Pharmacology and toxicology of infant skin. J Invest Dermatol 76:147–150
Greenblatt DJ, Koch-Weser J (1976) Intramuscular injection of drugs. N Engl J Med 295:542–546
Kafetzis DA, Sinaniotis CA, Papadatos CJ, Kosmidis J (1979) Pharmacokinetics of amikacin in infants and pre-school children. Acta Paediatr Scand 68:419–422
Sheng KT, Huang NN, Promadhattavedi V (1964) Serum concentrations of cephalothin in infants and children and placental transmission of the antibiotic. Antimicrob Agents Chemother 10:200–206
Windorfer A, Kuenzer W, Urbanek R (1974) The influence of age on the activity of acetylsalicylic acid-esterase and protein-salicylate binding. Eur J Clin Pharmacol 7:227–231
Tetelbaum M, Finkelstein Y, Nava-Ocampo AA, Koren G (2005) Back to basics: understanding drugs in children: pharmacokinetic maturation. Pediatr Rev 26:321–328
Gibaldi M (1984) Drug disposition-distribution. In: Biopharmaceutics and clinical pharmacokinetics, 3rd edn. Lea and Febiger, Philadelphia, pp 168–180
Leeder JS, Adcock K, Gaedlig K. Acquisition of CYP2D6 and CYP3A4 activities in the first year of life. Clin Pharmacol Ther. 2000;67:169(Abstract).
Ehrnebo M, Agurell S, Jalling B, Boreus LO (1971) Age differences in drug binding by plasma proteins: studies on human fetuses, neonates and adults. Eur J Clin Pharmacol 3:189–193
McNammara PJ, Alcorn J (2002) Protein binding predictions in infants. AAPS Pharma Sci 4:1–8
Gorodischer R, Jusko WJ, Yaffe SJ (1976) Tissue and erythrocyte distribution of digoxin in infants. Clin Pharmacol Ther 19:256–263
Kearin M, Kelly JG, O'Malley K (1980) Digoxin “receptors” in neonates: an explanation of less sensitivity to digoxin in adults. Clin Pharmacol Therap 28:346–349
Benedetti MS, Baltes EL (2003) Drug metabolism and disposition in children. Fund Clin Pharmacol 17:281–299
Niederhauser VP (1997) Prescribing for children: issues in pediatric pharmacology. Nurse Pract 22:16–18
Blanco JG, Harrison PL, Evans WE et al (2000) Human cytochrome P450 maximal activities in pediatric versus adult liver. Drug Metab Disp 28:379–382
de Wildt SN, Kearns GL, Leeder JS, van den Anker JN (1999) Cytochrome P450 3A: ontogeny and drug disposition. Clin Pharmacokinet 37:485–505
Lacroix D, Sonnier M, Moncion A, Cheron G, Cresteil T (1997) Expression of CYP3A in the human liver–evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth. Eur J Biochem 247:625–634
Pearce R, Greenway D, Parkinson A (1992) Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: effects on coumarin, dicumarol, and testosterone oxidation. Arch Biochem Biophys 298:211–225
Tateishi T, Nakura H, Asoh M, Watanabe M, Tanaka M et al (1997) A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy. Life Sci 61:2567–2574
Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989) Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci U S A 86:7696–7700
Sonnier M, Cresteil T (1998) Delayed ontogenesis of CYP1A2 in the human liver. Eur J Biochem 251:893–898
Bauer LA, Blouin R (1983) Phenytoin Michaelis-Menten PK in Caucasian paediatric patients. Clin Pharmacokinet 8:545–549
Chiba K, Ishizaki T, Miura H, Minagawa K (1980) Michaelis-Menten pharmacokinetics of diphenylhydantoin and application in the pediatric age patient. J Pediatr 96(3 Pt 1):479–484
Treluyer JM, Gueret G, Cheron G, Sonnier M, Cresteil T (1997) Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility. Pharmacogenetics 7:441–452
Leeder JS (2001) Pharmacogenetics and pharmacogenomics. Pediatr Clin North Am 48:765–781
Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN (2004) Developmental expression of human hepatic CYP2C9 and CYP2C19. J Pharmacol Exp Ther 308:965–974
Peng DR, Birgersson C, von Bahr C, Rane A (1984) Polymorphic acetylation of 7-amino-clonazepam in human liver cytosol. Pediatr Pharmacol 4:155–159
Daly AK, Brockmoller J, Broly F, Eichelbaum M, Evans WE et al (1996) Nomenclature for human CYP2D6 alleles. Pharmacogenetics 6:193–201
Jakoby WB, Ziegler DM (1990) The enzymes of detoxication. J Biol Chem 265:20715–20718
May DG (1994) Genetic differences in drug disposition. J Clin Pharmacol 34:881–897
de Wildt SN, Kearns GL, Leeder JS, van den Anker JN et al (1999) Glucuronidation in humans. Pharmacogenetic and developmental aspects. Clin Pharmacokinet 36:439–452
Onishi S, Kawade N, Itoh S, Isobe K, Sugiyama S (1979) Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver. Biochem J 184:705–707
Leakey JE, Hume R, Burchell B (1987) Development of multiple activities of UDP-glucuronyltransferase in human liver. Biochem J 243:859–861
Pacifici GM, Franchi M, Colizzi C, Giuliani L, Rane A (1988) Glutathione S-transferase in humans: development and tissue distribution. Arch Toxicol 6:265–269
Strange RC, Howie AF, Hume R, Matharoo B, Bell J (1989) The development expression of alpha-, mu- and pi-class glutathione S-transferases in human liver. Biochim Biophys Acta 993:186–190
Levy G, Khanna NN, Soda DM, Tsuzuki O, Stern L (1975) Pharmacokinetics of acetaminophen in the human neonate: formation of acetaminophen glucuronide and sulfate in relation to plasma bilirubin concentration and D-glucaric acid excretion. Pediatrics 55:818–825
McRorie TI, Lynn AM, Nespeca MK, Opheim KF, Slattery JT (1992) The maturation of morphine clearance and metabolism. AJDC 146:972–976
Pacifici GM, Bencini C, Rane A (1986) Acetyltransferase in humans: development and tissue distribution. Pharmacology 32:283–291
Pariente-Khayat A, Pons G, Rey E, Richard MO, D’Athis P (1991) Caffeine acetylator phenotyping during maturation in infants. Pediatr Res 29:492–495
Szorady I, Santa A, Veress I (1987) Drug acetylator phenotypes in newborn infants. Biol Res Pregnancy Perinatol 8:23–25
Tayama Y, Miyake K, Sugihara K, Kitamura S, Kobayashi M et al (2007) Developmental changes of aldehyde oxidase activity in young Japanese children. Clin Pharmacol Therap 81:567–572
Kornhuber J, Konradi C, Mack-Burkhardt F, Riederer P, Heinsen H et al (1989) Ontogenesis of monoamine oxidase-A and -B in the human brain frontal cortex. Brain Res 499:81–86
Riley LA, Waguespack MA, Denney RM (1989) Characterization and quantitation of monoamine oxidases A and B in mitochondria from human placenta. Mol Pharmacol 36:54–60
Kimura A, Mahara R, Inoue T, Nomura Y, Murai T et al (1999) Profile of urinary bile acids in infants and children: developmental pattern of excretion of unsaturated ketonic bile acids and 7beta-hydroxylated bile acids. Pediatr Res 45(4 Pt 1):603–609
Shargel L, Yu ABC (1993) Drug clearance. In: Introduction to pharmacokinetics: applied biopharmaceutics and pharmacokinetics, 3rd edn. Appleton & Lange, Norwalk, pp 265–292
Arant BS Jr (1978) Developmental patterns of renal functional maturation compared in the human neonate. J Pediatr 92:705–712
Brown RD, Campoli-Richards M (1989) Antimicrobial therapy in neonates, infants and children. Clin Pharmacokinet 17:105–115
Jacobs RF, Kearns GL, Brown AL, Trang HM, Kluza RB (1984) Renal clearance of imipenem in children. Eur J Microbiol 3:471–474
Gibaldi M (1984) Drug disposition-elimination. In: Biopharmaceutics and clinical pharmacokinetics, 3rd edn. Lea & Febiger, Philadelphia, pp 181–205
Jones DP, Chesney RW (1992) Development of tubular function. Clin Perinatol 19:33–57
Hua MJ, Kun HY, Jie CS, Yun NZ, De WQ et al (1997) Urinary microalbumin and retinol-binding protein assay for verifing children’s nephron development and maturation. Clin Chim Acta 264:127–132
Work DF, Schwartz GJ (2008) Estimating and measuring glomerular filtration rate in children. Curr Opin Nephrol Hypertens 17:320–325
Schwartz GJ, Work DF (2009) Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol 4:1832–1843
Marshall JD, Kearns GL (1999) Developmental pharmacodynamics of cyclosporine. Clin Pharmacol Ther 66:66–75
Schwartz GJ, Muñoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629–637
Bacchetta J, Cochat P, Rognant N, Ranchin B, Hadj-Aissa A, Dubourg L (2011) Which creatinine and cystatin C equations can be reliably used in children? Clin J Am Soc Nephrol 6:552–560
Pottel H, Hoste L, Martens F (2012) A simple height-independent equation for estimating glomerular filtration rate in children. Pediatr Nephrol 27:973–979
Pottel H, Vrydags N, Mahieu B, Vandewynckele E, Croes K, Martens F (2008) Establishing age/sex related serum creatinine reference intervals from hospital laboratory data based on different statistical methods. Clin Chim Acta 396:49–55
Thomas C, Thomas L (2009) Renal Failure-Measuring the glomerular filtration rate. Dtsch Arztebl Int 106:849–854
Grubb A, Nyman U, Björk J, Lindström V, Rippe B, Sterner G, Christensson A (2005) Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem 51:1420–1431
Kauffman RE, Lieh-Lai MW, Uy HG, Aravind MK (1999) Enantiomer-selective pharmacokinetics and metabolism of ketorolac in children. Clin Pharmacol Ther 65:382–388
Lynn AM, Bradford H, Kantor ED, Seng KY, Salinger DH, Chen J, Ellenbogen RG, Vicini P, Anderson GD (2007) Postoperative ketorolac tromethamine use in infants aged 6–18 months: the effect on morphine usage, safety assessment, and stereo-specific pharmacokinetics. Anesth Analg 104:1040–1051
Bressolle F, Rochette A, Khier S, Dadure C, Ouaki J, Capdevila X (2009) Population pharmacokinetics of the two enantiomers of tramadol and O-demethyl tramadol after surgery in children. Br J Anaesth 102:390–399
Takahashi H, Ishikawa S, Nomoto S, Nishigaki Y, Ando F et al (2000) Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children. Clin Pharmacol Ther 68:541–555
Dong JQ, Ni L, Scott CS, Retsch-Bogart GZ, Smith PC (2000) Pharmacokinetics of ibuprofen enantiomers in children with cystic fibrosis. J Clin Pharmacol 40:861–868
Stephenson T (2005) How children’s responses to drugs differ from adults. Br J Clin Pharmacol 59:670–673
Padbury JF (1998) Neonatal dopamine pharmacodynamics: lessons from the bedside. J Pediatr 133:719–720
Seri I, Abbasi S, Wood DC, Gerdes JS (1998) Regional hemodynamic effects of dopamine in the sick preterm neonate. J Pediatr 133:728–734
Tran A, Rey E, Pons G, Pariente-Khayat A, d’Athis P et al (2002) Pharmacokinetic-pharmacodynamic study of oral lansoprazole in children. Clin Pharmacol Ther 71:359–367
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Mahmood, I. (2016). Developmental Pharmacology: Impact on Pharmacokinetics and Pharmacodynamics of Drugs. In: Mahmood, I., Burckart, G. (eds) Fundamentals of Pediatric Drug Dosing. Adis, Cham. https://doi.org/10.1007/978-3-319-43754-5_3
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