Fundamentals of Pediatric Drug Dosing

  • Iftekhar Mahmood
  • Gilbert Burckart

Table of contents

  1. Front Matter
    Pages i-viii
  2. Iftekhar Mahmood
    Pages 13-22
  3. Dionna Green, Valerie Amspacher
    Pages 45-63
  4. Jeremiah D. Momper, John Bradley, Brookie M. Best
    Pages 83-92
  5. Ine Skottheim Rusten, Anna Nordmark, Susan Cole, Joseph F. Standing, Sofia Friberg Hietala, Wei Zhao et al.
    Pages 93-107
  6. Iftekhar Mahmood, Gilbert J. Burckart, Robert M. Ward
    Pages 127-146

About this book

Introduction

Focused on pediatric physiology, pharmacology, pharmacokinetics and pharmacodynamics, this book illustrates the differences between the pediatric population and adults; knowledge of extreme importance not only during pediatric drug development but also in the clinical practice. Physicians, nurses, clinical pharmacologists, researchers and healthcare professionals will find this an invaluable resource. 

With the advent of pediatric exclusivity, and requirements to conduct clinical studies in children, an emphasis has been placed on finding a safe and efficacious dose of a drug in children. Children are not ‘small adults’, and drug dosing in this population requires special consideration. There are subtle physiological and biochemical differences among neonates, infants, children, adolescents and adults and dosing in pediatrics requires proper understanding of these factors. Furthermore, dosing in children, as in adults, should be based on pharmacokinetic and pharmacodynamic data. This is an evolving area, as pediatric pharmacokinetic studies are becoming mandatory for getting approval of new drugs in this population.

Keywords

Allometric Scaling Clinical Pharmacology Pediatric Clinical Trial Pharmacokinetic Modeling Pharmacokinetic Simulation Physiologically Based Pharmacokinetic Modeling

Editors and affiliations

  • Iftekhar Mahmood
    • 1
  • Gilbert Burckart
    • 2
  1. 1.Clinical Pharmacology/BiopharmaceuticsFood & Drug AdministrationSilver SpringUSA
  2. 2.Clinical PharmacologyFood & Drug Administration, Pediatric GroupSilver SpringUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-43754-5
  • Copyright Information Springer International Publishing Switzerland 2016
  • Publisher Name Adis, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-319-43752-1
  • Online ISBN 978-3-319-43754-5
  • About this book
Industry Sectors
Biotechnology
Consumer Packaged Goods
Pharma