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How to Treat EGJ Cancer: Indications and Treatment Strategy

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Adenocarcinoma of the Esophagogastric Junction

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Abstract

Esophagogastric junction (EGJ) adenocarcinoma has been differently classified over time. In 1996, Siewert and coworkers introduced a classification (AEG classification or Siewert classification) for this cancer, which has been adopted by the ISDE congress in 1997 and it was used without modifications ever since. It is undoubtedly the most used classification for EGJ cancer worldwide.

Surgery with lymphadenectomy has always been considered the standard approach to EGJ cancer, with some differences due to Siewert type. Aims of surgery are reaching a curative R0 resection and good survival. Surgical choices are based on neoplastic diffusion, which differs based on cancer site and depth of cancer invasion in the wall of esophagus and stomach.

In this chapter, indications and treatment strategy for all Siewert types are described, with particular interest on surgical margins, lymphadenectomy, and surgical approach.

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Authors and Affiliations

  1. Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

    Andrea Zanoni, Simone Giacopuzzi & Giovanni de Manzoni

  2. Upper Gastrointestinal and General Surgery, University of Verona, Piazzale Aristide Stefani, 1, Verona, 37126, Italy

    Silvia Laiti

  3. Unit of General Surgery, Rovereto Hospital, APSS of Trento, Corso Verona, 4, Rovereto (TN), 38068, Italy

    Alberto Di Leo

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    Simone Giacopuzzi

  2. Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

    Andrea Zanoni

  3. Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

    Giovanni de Manzoni

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Zanoni, A., Giacopuzzi, S., Laiti, S., Di Leo, A., de Manzoni, G. (2017). How to Treat EGJ Cancer: Indications and Treatment Strategy. In: Giacopuzzi, S., Zanoni, A., de Manzoni, G. (eds) Adenocarcinoma of the Esophagogastric Junction. Springer, Cham. https://doi.org/10.1007/978-3-319-28776-8_14

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