Adenocarcinoma of the Esophagogastric Junction

1. Front Matter

   Pages i-xv

   PDF

2. Epidemiology and Risk Factors

   • Giuseppe Verlato, Giovanni De Manzoni

   Pages 1-9

3. Barrett’s Esophagus: Pathogenesis and Prevention

   • Janusz Jankowski, Amritpal Dhaliwal, Michael McFarlane

   Pages 11-16

4. Surveillance in Barrett’s Esophagus and Dysplasia

   • Luca Faccio, Giovanni Zaninotto

   Pages 17-23

5. Ablation Techniques for Barrett’s Esophagus and Dysplasia

   • Prashanthi N. Thota

   Pages 25-34

6. Endoscopic Resection for Barrett’s Esophagus to Dysplasia

   • Filippo Catalano

   Pages 35-39

7. 7th Edition AJCC/UICC Staging: Esophagus and Esophagogastric Junction

   • Thomas W. Rice

   Pages 41-46

8. Siewert Classification of Adenocarcinoma of the Esophagogastric Junction: Still In or Already Out?

   • Paul M. Schneider, Stefan P. Mönig

   Pages 47-56

9. Preoperative Work-Up: Conventional Radiology, CT Scan, Ultrasonography, and MRI

   • Angela M. Riddell

   Pages 57-65

10. Role of PET/CT and MRI in the Prediction of Response to Neoadjuvant Treatment

    • Daniela Cenzi, Lisa Zantedeschi, Michele Zuffante, Endrit Strazimiri, Stefania Montemezzi

    Pages 67-83

11. Molecular Markers in the Prediction of Response to Neoadjuvant Treatments in Esophagogastric Junction Adenocarcinoma

    • Davide Melisi, Melissa Frizziero, Geny Piro, Giampaolo Tortora

    Pages 85-94

12. Pathological Response to Neoadjuvant Treatment: More Questions Than Answers

    • Andrea Zanoni, Simone Giacopuzzi, Anna Tomezzoli, Maria Bencivenga, Giovanni de Manzoni

    Pages 95-99

13. Hospital Volume and Centralization in EGJ Cancer

    • Riccardo Rosati, Uberto Fumagalli Romario

    Pages 101-105

14. Patient Selection and Tailored Treatment Principles

    • Francesco Casella, Andrea Zanoni, Simone Giacopuzzi, Andrea Sansonetti, Giovanni de Manzoni

    Pages 107-116

15. How to Treat EGJ Cancer: Indications and Treatment Strategy

    • Andrea Zanoni, Simone Giacopuzzi, Silvia Laiti, Alberto Di Leo, Giovanni de Manzoni

    Pages 117-137

16. Chemotherapy in Oesophagogastric Junctional Cancer

    • Paul M. Wilkerson, Stephen T. Hornby, William H. Allum

    Pages 139-148

17. Chemoradiation in Esophagogastric Junction Cancer

    • Bo J. Noordman, Bas P. L. Wijnhoven, Joel Shapiro, Maarten C. C. M. Hulshof, Ate van der Gaast, Jan J. B. van Lanschot

    Pages 149-161

18. Signet Ring Carcinoma in EGJ: What Is It?

    • Riccardo Piagnerelli, Daniele Marrelli, Franco Roviello

    Pages 163-169

19. Morbid-Mortality and Treatment of Complications

    • Jacopo Weindelmayer, Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni

    Pages 171-184

20. Long-Term Results with Surgery Alone and Multimodal Treatments

    • Andrea Zanoni, Simone Giacopuzzi, Elio Treppiedi, Jacopo Weindelmayer, Giovanni de Manzoni

    Pages 185-191

This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.

• EGJ cancer
• Multimodal treatment
• Neoadjuvant treatments
• Preneoplastic lesions
• Cancer staging for EGJ cancer
• surgical oncology
• abdominal surgery

“This is a comprehensive book dedicated to the spectrum of changes from Barrett's esophagus through adenocarcinoma of the esophagogastric junction. … This is a book for specialists -- gastroenterologists, surgeons, medical and radiation oncologists. … This is a useful book that will find a place as a specialized reference, reflecting a distinctly European approach to management of this increasingly common malignancy.” (Carol Scott-Conner, Doody's Book Reviews, May, 2017)

• Upper Gastrointestinal and General Surgery, University of Verona, Verona, Italy

  Simone Giacopuzzi, Andrea Zanoni, Giovanni de Manzoni

Simone Giacopuzzi graduated in Medicine from the University of Verona in 2002 and gained a Degree in General Surgery (70/70 and distinction) from the University of Verona in May 2008. During 2009 he spent 6 months as an observer at Fujita Health University, where he completed a training program in laparoscopic upper digestive surgery. Since 2009 he has worked as a General Surgeon in the Department of Upper GI Surgery at Verona Hospital. Since January 2013 he has also attended the PhD course at the Department of Surgery, University of Verona. He has cooperated with the Scientific Committee of the 10th IGCC (International Gastric Cancer Congress) as chairman of the web round table, “Laparoscopy and robotic treatment. What is evidence based?” Dr. Giacopuzzi is author or co-author of 20 indexed journal articles and co-author of a book on esophageal cancer. His research interests include surgical oncology for solid tumors, especially upper GI cancer, and minimally invasive surgery.

Andrea Zanoni graduated cum laude in Medicine from the University of Verona in 2006 and specialized cum laude in General and Emergency Surgery at the University of Verona in 2013. He was an international observer at the Department of Thoracic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA from November 2012 to April 2013 and is at present a research fellow at the Department of Upper GI Surgery at the University of Verona. He is the author of five scientific articles in international and Italian journals and co-author of a book on squamous cell carcinoma of the esophagus. Dr. Zanoni is a reviewer for an international journal on esophageal diseases and was involved, with the Scientific Committee, in the organization of the 10th IGCC, held in Verona in 2013. He was a speaker at the 12th and 13th World Congresses of the International Society for Diseases of the Esophagus.

Giovanni de Manzoni is Full Professor of Surgery and a Consultant in the Department of Surgery, University of Verona, Italy. He is President of the International Gastric Cancer Association for the years 2013-2015 and Coordinator and General Secretary of the Italian Research Group for Gastric Cancer. He is also a longstanding member of the International Gastric Cancer Association and the Advisory Board of the Brazilian Gastric Cancer Association. Dr. de Manzoni is a member of the editorial board of Gastric Cancer, official journal of the International Gastric Cancer Association. His clinical and research activity focuses on (among other topics) surgical oncology for solid tumors, extended lymphadenectomy in upper GI cancer, and tumor prognostic factors and staging. He is the author of various books and over 160 articles in PubMed-cited journals. 

Policies and ethics