Abstract
Radiochemotherapy for malignancies of the head and neck area has its limits in locally extremely advanced invasive tumors with high volume. Although a large variety of locoregional modes of drug administration have been reported so far, ranging from intra-arterial long-term infusion to superselective supradose infusion or chemoembolization, the short-term exposure of high concentrations of cytotoxics by means of intra-arterial infusion over median 7 min in an isolated thoracic perfusion circuit seems to generate superior response rates. In two patients with systemically pretreated and nonresponding bulky high-volume cancers of the parotid gland, isolated thoracic perfusion with carotid artery infusion led to substantial tumor shrinkage and local resectability.
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Aigner, K.R., Selak, E., Schlaf, R. (2016). Isolated Thoracic Perfusion with Carotid Artery Infusion for Advanced and Chemoresistant Tumors of the Parotid Gland and Tonsils. In: Aigner, K., Stephens, F. (eds) Induction Chemotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-28773-7_8
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DOI: https://doi.org/10.1007/978-3-319-28773-7_8
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