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Induction Chemotherapy

Systemic and Locoregional

  • Describes the applications of induction chemotherapy in different cancer types
  • Presents integrated treatment practices used in various renowned institutions
  • Devotes detailed attention to pioneering and cutting-edge practices and research
  • Discusses patient selection
  • Explains the importance of comprehensive cancer centers

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Table of contents (33 chapters)

  1. Front Matter

    Pages i-vii
  2. Drug Removal Systems and Induction Chemotherapy

    • James H. Muchmore
    Pages 31-43
  3. Cryotherapy

    • Miriam R. Habib, David L. Morris
    Pages 45-51
  4. Local and Regional Hyperthermia

    • Miriam R. Habib, David L. Morris
    Pages 53-60
  5. The Role of Hypoxia and Hyperthermia in Chemotherapy

    • Giammaria Fiorentini, Maurizio Cantore, Francesco Montagnani, Andrea Mambrini, Michelina D’Alessandro, Stefano Guadagni
    Pages 61-71
  6. Induction Chemotherapy in Head and Neck Cancers

    • Adorján F. Kovács
    Pages 73-122
  7. Induction Chemotherapy for Breast Cancer

    • François-Michel Delgado, Maria Angeles Gil-Delgado, David Khayat
    Pages 131-156
  8. Patients with Locally Advanced Breast Cancer Receiving Intra-arterial Induction Chemotherapy: Report of a Phase II Clinical Study

    • Giammaria Fiorentini, Camillo Aliberti, Paolo Coschiera, Virginia Casadei, Luca Mulazzani, Anna Maria Baldelli et al.
    Pages 157-171
  9. Regional Chemotherapy for Thoracic Wall Recurrence and Metastasized Breast Cancer

    • Karl Reinhard Aigner, Stefano Guadagni, Giuseppe Zavattieri
    Pages 173-186
  10. Cytoreductive Surgery and “Hyperthermic Intraperitoneal Chemotherapy (HIPEC)”

    • Markus Hirschburger, Winfried Padberg
    Pages 187-211
  11. Esophageal Cancer

    • Tetsuo Taguchi
    Pages 225-229
  12. Gastric Cancer

    • Tetsuo Taguchi
    Pages 231-242
  13. Systemic and Regional Chemotherapy for Advanced and Metastasized Pancreatic Cancer

    • Karl Reinhard Aigner, Sabine Gailhofer, Gur Ben-Ari
    Pages 243-251
  14. Induction Chemotherapy for Hepatocellular Carcinoma

    • Takumi Fukumoto, Yonson Ku
    Pages 269-284

About this book

This book presents the full range of management techniques and practices used in induction chemotherapy – both systemic and locoregional - by experienced international groups within one accessible volume. It provides the latest information on the pioneering and cutting-edge practices employed in different institutions and documents the advantages of integrated treatment schedules. All those responsible for treating patients with locally advanced cancers may find new, interesting aspects of locoregional cancer management and will find this book to be an invaluable source of up-to-date information.

Throughout the world, induction chemotherapy is being used as part of an integrated plan of management for locally advanced, solid tumors, while systemic chemotherapy is most commonly used to shrink primarily non-operable tumors. In cases of poorly or nonresponsive tumors, attempts have been made to administer chemotherapeutics via the arterial route in order to achieve higher localized drug exposure and response rates. Such therapies are being practiced worldwide in independent, remote departments in universities, teaching hospitals and clinical schools. Frequently, however, these teams remain relatively unaware of the work being done in other institutions, which may slow further progress.

Editors and Affiliations

  • Department of Surgical Oncology, Medias Klinikum GmbH & Co KG, Burghausen, Germany

    Karl Reinhard Aigner

  • Royal Prince Alfred, Sydney Hospitals, Mosman, Australia

    Frederick O. Stephens

About the editors

Professor Dr. med. Aigner is one of the world’s pioneers in the field of regional chemotherapy. He has been involved with regional chemotherapy for over 30 years and today he is considered as one of the world’s most experienced experts in this treatment method. Numerous lectures and guest operations in the USA, Japan, China, Israel, Egypt, Australia and a number of other countries, as well as over 200 professional publications, lectures and guest operations both in Germany and abroad attest to his medical commitment to RCT – regional chemotherapy.


Prof. Aigner completed his medical studies and his basic surgical training in cardiovascular surgery at the University of Erlangen. He obtained his habilitation doctorate in surgical oncology at the University of Giessen, with a research focus in techniques of regional chemotherapy. In 1981, Prof Aigner developed a technique for performing the first isolated liver perfusion in humans using a heart-lung machine, and over subsequent years a variety of additional surgical procedures and specialized catheters for isolated therapy of organs and parts of the body, including the treatment of pancreatic carcinoma.

From 1986 until 1991, Prof. Aigner was Chief Physician for Surgery at the Kreiskrankenhaus Trostberg am Chiemsee, and until 2001, he was the Chief Physician in the Department of Oncological Surgery at the Asklepios Paulinen Clinic in Wiesbaden. From 2002 until 2005 he led the Department of oncological surgery at the Medias Klinik GmbH in Ransbach-Baumbach. Since 2006 Prof. Aigner has been the Medical Director of the Medias Klinikum GmbH & Co KG, a private clinic for oncological surgery in Burghausen (Salzach).

Professor Emeritus Fred Stephens is a global authority in innovative approaches to the treatment of previously incurable cancers. From his base at Sydney University, Professor Stephens was an early pioneer in Regional Chemotherapy, with experience spanning over four decades. His remarkable results gained international attention as he was invited to deliver keynote speeches and lectures at over thirty international conferences at Universities spanning Germany, France, the UK, USA, Japan, Israel, Austria, Hungary and of course, Australia. In 1988 Prof Stephens' pre-eminence in Regional Chemotherapy was formally recognised with his election as Foundation President of the International Society for Regional Cancer Therapy, a position he held until succeeded by Prof Aigner in 1995.


One of three Managing Editors of the journal Regional Cancer Treatment (now incorporated in the European Journal of Surgical Oncology) Prof Stephens has published extensively, both on Regional Chemotherapy and on Cancer more broadly. These include over 200 publications within refereed medical journals (of which 67 are single author publications); three Cancer textbooks and five books on Cancer for laypeople. 

Prof Stephens doctorate (MD) in Surgical Oncology was conferred by Sydney University in 1970. His Master of Surgery (MS) was conferred by Sydney University the same year. As Associate Professor of Surgery, Dr Stephens developed his treatment protocols while building a strong clinical/research team; first at Sydney Hospital, then at the Royal Prince Alfred Hospital from 1985. He accepted the role of Professor of Surgical Oncology (and Head of Surgery) for the University of Sydney in 1988. On his retirement in 1995, Prof Stephens was conferred the distinction of a personal chair (Professor Emeritus) in Surgical Oncology, in recognition of his outstanding contributions to the field of Regional Chemotherapy:- his protocols in Regional Chemotherapy have gained wide acceptance at Universities and medical centres of excellence worldwide. Most recently (2015), he has concluded an agreement with Macquarie University for the establishment of Australia's first permanent chair in Surgical Oncology.

Bibliographic Information

  • Book Title: Induction Chemotherapy

  • Book Subtitle: Systemic and Locoregional

  • Editors: Karl Reinhard Aigner, Frederick O. Stephens

  • DOI: https://doi.org/10.1007/978-3-319-28773-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2016

  • Hardcover ISBN: 978-3-319-28771-3Published: 06 June 2016

  • Softcover ISBN: 978-3-319-80420-0Published: 30 May 2018

  • eBook ISBN: 978-3-319-28773-7Published: 27 May 2016

  • Edition Number: 2

  • Number of Pages: VII, 506

  • Number of Illustrations: 45 b/w illustrations, 86 illustrations in colour

  • Topics: Oncology, Surgery, Interventional Radiology, General Practice / Family Medicine

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buy it now

Buying options

eBook USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access