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Drug Release

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Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Part of the book series: Interdisciplinary Applied Mathematics ((IAM,volume 30 ))

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Abstract

The term “release” encompasses several processes that contribute to the transfer of drug from the dosage form to the bathing solution (e.g., gastrointestinal fluids, dissolution medium).

An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived. … The amount of drug released … is proportional to the square root of time.

Takeru Higuchi School of Pharmacy, University of Wisconsin, Madison Journal of Pharmaceutical Sciences 50:874–875 (1961)

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Notes

  1. 1.

    The terms “drug molecule” and “particle” will be used in this section interchangeably.

  2. 2.

    The classical kinetics solution is obtained by solving (4.13) in case of \(g\left (t\right ) = 1\).

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Authors and Affiliations

  1. Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece

    Panos Macheras

  2. Faculty of Pharmacy, Aix-Marseille University, Marseille, France

    Athanassios Iliadis

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  1. Panos Macheras
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  2. Athanassios Iliadis
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Macheras, P., Iliadis, A. (2016). Drug Release. In: Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics. Interdisciplinary Applied Mathematics, vol 30 . Springer, Cham. https://doi.org/10.1007/978-3-319-27598-7_4

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