Table of contents
About this book
The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body.
The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.
This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.
Reviews of the first edition:
"This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007)
authors are the unique (or sole) contributors in this area that are
working on these questions and bring a special expertise to the field
that is now being recognized as essential to understanding biological
system and kinetic/dynamic characteristics in drug development...This
text is an essential primer for those who would envision the
incorporation of heterogeneous approaches to systems where homogeneous
approaches are not sufficient to describe the system." (Robert R. Bies,
Journal of Clinical Pharmacology, Vol. 46, 2006)
- DOI https://doi.org/10.1007/978-3-319-27598-7
- Copyright Information Springer International Publishing Switzerland 2016
- Publisher Name Springer, Cham
- eBook Packages Mathematics and Statistics
- Print ISBN 978-3-319-27596-3
- Online ISBN 978-3-319-27598-7
- Series Print ISSN 0939-6047
- Series Online ISSN 2196-9973
- About this book