Abstract
A great body of evidence supports the statement that both genetic and epigenetic processes are responsible for tumor development. Indeed, alterations in DNA methylation, histone modifications, polycomb, miRNAs, and chromatin remodeling complex function are mechanisms that directly contribute to tumorigenesis. However, this chapter will summarize the most relevant genetic alterations, which contribute to the regulation of cancer stem cell features in tumor progression, metastasis, and response to chemotherapy.
If you wish to make an apple pie from scratch, you must first invent the universe.
Carl Sagan, Cosmos
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References
Munoz P, Iliou MS, Esteller M (2012) Epigenetic alteration involved in cancer stem cell reprogramming. Mol Oncol 6(6):620–636
Esteller M (2012) Cancer, epigenetics and the Nobel Prizes. Mol Oncol 6(6):565–566
Woll PS, Kjällquist U, Chowdhury O et al (2014) Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo. Cancer Cell 25(6):794–808. doi:10.1016/j.ccr.2014.03.036
Pabst C, Krosl J, Fares I, Boucher G, Ruel R, Marinier A, Lemieux S, Hébert J, Sauvageau G (2014) Identification of small molecules that support human leukemia stem cell activity ex vivo. Nat Methods 11(4):436–442. doi:10.1038/nmeth.2847
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Pavlovic, M., Balint, B. (2015). Genetic Mechanisms Involved in Cancer Stem Cell Emergence. In: Bioengineering and Cancer Stem Cell Concept. Springer, Cham. https://doi.org/10.1007/978-3-319-25670-2_5
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DOI: https://doi.org/10.1007/978-3-319-25670-2_5
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Publisher Name: Springer, Cham
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Online ISBN: 978-3-319-25670-2
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