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Delta Opioid Receptor and Peptide: Hibernation for Stroke Therapy

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Neural Functions of the Delta-Opioid Receptor

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Abstract

In pursuit of neurological therapies, the opioid system, specifically delta opioids and delta opioid peptides, demonstrates promising potential for stroke, Parkinson’s Disease, and other degenerative neurological conditions. Recent studies present strong evidence in support of the therapeutic use of delta opioid receptors, and provide insight into the underlying mechanisms of action. Delta opioid receptors have been shown to confer protective effects by mediating ionic homeostasis and activating endogenous neuroprotective pathways. Additionally, delta opioid agonists such as (D-Ala 2, D-Leu 5) enkephalin (DADLE) have been shown to decrease apoptosis and promote neuronal survival. In its entirety, the delta opioid system represents a promising target for neural therapies.

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Abbreviations

DADLE:

(D-Ala 2, D-Leu 5) enkephalin

DAT:

Dopamine transporter

DOR:

Delta (δ) opioid receptor

HIT:

Hibernation Induction Trigger

KOR:

Kappa (κ) opioid receptor

MAPK:

Mitogen-activated protein kinase

MCAO:

Middle Cerebral Artery Occlusion

METH:

Methamphetamine

MOR:

Mu (μ) opioid receptor

PKC:

Protein kinase c

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Acknowledgements

This study was supported by the National Institutes of Health (1RO1NS071956-01A1) and the James and Easter King Biomedical Research Program (1KG01-33966).

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Authors and Affiliations

  1. Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, 33612, USA

    Meaghan Staples, Sandra Acosta Ph.D., Naoki Tajiri P.T., Ph.D., Mibel Pabon Ph.D., Yuji Kaneko Ph.D. & Cesar V. Borlongan Ph.D.

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  1. Meaghan Staples
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  2. Sandra Acosta Ph.D.
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  3. Naoki Tajiri P.T., Ph.D.
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  4. Mibel Pabon Ph.D.
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  5. Yuji Kaneko Ph.D.
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  6. Cesar V. Borlongan Ph.D.
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Corresponding author

Correspondence to Cesar V. Borlongan Ph.D. .

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Editors and Affiliations

  1. Univ of Texas Med Schl, Houston, Texas, USA

    Ying Xia

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Staples, M., Acosta, S., Tajiri, N., Pabon, M., Kaneko, Y., Borlongan, C.V. (2015). Delta Opioid Receptor and Peptide: Hibernation for Stroke Therapy. In: Xia, Y. (eds) Neural Functions of the Delta-Opioid Receptor. Springer, Cham. https://doi.org/10.1007/978-3-319-25495-1_10

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