Neural Functions of the Delta-Opioid Receptor

1. Front Matter

   Pages i-xv

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2. Current Research on the δ-Opioid Receptor: From Neuroprotection Against Hypoxia/Ischemia to Broad Neural Functions

   • Ying Xia

   Pages 1-44

3. Recent History on Delta Opioid Receptors and Ligands: Biased Mechanisms, and Opioid Delta-Mu and Delta-Kappa Receptor Heteromers

   • Kwen-Jen Chang, Shoupu Yi, Yuehai Shen

   Pages 45-65

4. Evolutionary Distribution of the δ-Opioid Receptor: From Invertebrates to Humans

   • Taylor E. Hinchliffe, Ying Xia

   Pages 67-87

5. Developmental Distribution of the δ-Opioid Receptor in Mammalian Brains

   • Taylor E. Hinchliffe, Ying Xia

   Pages 89-115

6. The Role of δ-Opioid Receptors in Brain Ionic Homeostasis Under Physiological Condition

   • Dongman Chao, Ying Xia

   Pages 117-246

7. The δ-Opioid Receptor and Stabilization of Brain Ionic Homeostasis in Hypoxia/Ischemia

   • Dongman Chao, Ying Xia

   Pages 247-348

8. Regulation of Membrane Transporters by Delta-Opioid Receptors

   • Lu Pu, Yinfang Xu, Wolfgang Schwarz

   Pages 349-361

9. Neuroprotective Interactions Between Delta-Opioid Receptors and Glutamatergic Signaling Mediate Hypoxia-Tolerance in Brain

   • Matthew E. Pamenter

   Pages 363-388

10. δ-Opioids and Neurogenesis

    • Naoko Kuzumaki, Minoru Narita

    Pages 389-398

11. Delta Opioid Receptor and Peptide: Hibernation for Stroke Therapy

    • Meaghan Staples, Sandra Acosta, Naoki Tajiri, Mibel Pabon, Yuji Kaneko, Cesar V. Borlongan

    Pages 399-408

12. An Important Role of the δ-Opioid Receptor in Electroacupuncture-Induced Protection Against Ischemic Brain Injury

    • Tetsuya Asakawa, Ying Xia

    Pages 409-435

13. Delta Opioid Receptor in Cerebral Preconditioning

    • Jason Eli Maas, Zhiyi Zuo

    Pages 437-446

14. Delta-Opioid Receptor-Mediated Protection and Mitochondria

    • Jingchun Guo

    Pages 447-460

15. The Delta-Opioid System in the Brain: A Neglected Element in Parkinson’s Disease?

    • Dongman Chao, Ying Xia

    Pages 461-520

16. Are δ-Opioid Receptors Involved in Deep Brain Stimulation?

    • Albert J. Fenoy, Ying Xia

    Pages 521-581

17. Acupuncture, Opioid Receptors and Na+ Channels: A Novel Insight into Inhibition of Epileptic Hyperexcitability

    • Dongman Chao, Ying Xia

    Pages 583-605

18. Delta Opioids in Protection of the Heart and Brain

    • Jan M. Schilling, Daniel N. Deussen, David M. Roth, Hemal H. Patel

    Pages 607-630

19. The Various Functions of Opioids in Pathophysiological Conditions

    • Huimin Gao, Dongman Chao, Sebastian J. Villarreal, Daniel Yiu, Guoqiang Wen, Tao Chen et al.

    Pages 631-685

This book is the first to summarize the progress of research on neural functions of the the delta opioid receptor (DOR) to date. This receptor, a member of the opioid receptor family, was traditionally thought to be primarily involved in pain modulation. Recent new findings have shown its unique role in neuroprotection and many other functions. Many scientists from a number of independent laboratories have now confirmed that DOR can provide neuroprotection against hypoxic/ischemic injuries. They have also found that it plays a role in a variety of physiological and pathophysiological events such as hypoxic encephalopathy, epilepsy, acupuncture, Parkinson's disease, etc. by regulating ionic homeostasis, glutamate transportation and signaling, and balancing intracellular survival/death signals. The book will provide a comprehensive overview of the current state of DOR research and provide a blueprint for future directions.​

• delta opioid receptor
• hypoxic/ischemic injury
• neuroprotection
• opioid receptors
• neurogenesis

“Recent development in research dedicated to the function of δ-opioid receptors (DORs) is reviewed in this book. … Book may serve for graduated as well as undergraduated students who wish to get better insight into topics covered by individual chapters. It will be indispensable reference book for scientists working on any aspect of opioid research.” (Lubica Lacinova, General Physiology and Biophysics, Vol. 35 (4), 2016)

• Univ of Texas Med Schl, Houston, USA

  Ying Xia

Dr. Ying Xia is Professor and Vice-Chairman for Research of the Department of Neurosurgery at The University of Texas Medical School at Houston, and Professor of Neuroscience at The University of Texas at Houston Graduate School of Biomedical Sciences. He obtained his medical training at Soochow Medical College, China and his Master Degree of Medicine and Doctoral Degree of Medical Science (Ph.D.) in Neurobiology and Integrative Medicine at Shanghai Medical University, China. Dr. Xia joined Yale University School of Medicine for his postdoctoral training and established his laboratory at Yale. During his 22-year academic career at Yale University School of Medicine, he was appointed as a faculty member in 1993 and promoted to Associate Professor in 2002. He joined the University of Texas Medical School at Houston in May 2010.

Dr. Xia’s research has been consecutively supported by various funding agencies such as NIH, America Heart Association, March of Dimes Foundation, Cerebral Palsy Foundation and The Vivian L. Smith Neurologic Foundation since the establishment of his laboratory. He has been invited to deliver speeches by many academic institutions and international conferences. He is a reviewer for many international journals and serves as a grant reviewer for NIH, US National Science Foundation, other American and European foundations, Hong Kong University Grants Committees, and Natural Science Foundation of China.

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