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Emerging Systemic and Targeted Therapies

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Multimodality Management of Borderline Resectable Pancreatic Cancer

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Abstract

Pancreatic cancer is a systemic disease in the majority of newly diagnosed patients, including those who present with localized resectable disease. Systemic therapy with or without radiotherapy has become a standard of care for patients with localized pancreatic cancer (LPC), (NCCN guidelines version 2.2015), and the role of radiotherapy continues to be debated. Over the past decade there have been an increasing number of systemic agents that have demonstrated clinical benefit in patients with advanced pancreatic cancer. Unfortunately, these advances have been modest at best. Furthermore, despite continued improvements in our knowledge of the molecular biology of pancreas cancer, improvements in survival with multiple target agents have also been poor. The complexity of genetic and epigenetic abnormalities in pancreatic adenocarcinoma and the lack of clear driver mutations challenge the successful development of targeted agents. Newer treatment approaches such as targeting the signal pathways in the stroma and immunotherapy hold promise for the future. In this chapter we will provide an overview of the current therapies, highlight some of the failed treatment strategies, and describe the newer approaches that are currently in development.

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  1. Department of Oncology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Center, Detroit, MI, USA

    Trailokya Pandit & Philip A. Philip

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  1. Trailokya Pandit
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  2. Philip A. Philip
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  1. Department of Surgical Oncology, MD Anderson Cancer Center, Houston, Texas, USA

    Matthew H.G. Katz

  2. Division of Surgical Oncology, The University of Cincinnati Medical Center, Cincinnati, Ohio, USA

    Syed A. Ahmad

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Pandit, T., Philip, P.A. (2016). Emerging Systemic and Targeted Therapies. In: Katz, M., Ahmad, S. (eds) Multimodality Management of Borderline Resectable Pancreatic Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-22780-1_10

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  • DOI: https://doi.org/10.1007/978-3-319-22780-1_10

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