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Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities

  • Chapter
The Formation, Structure and Activity of Phytochemicals

Part of the book series: Recent Advances in Phytochemistry ((RAPT,volume 45))

Abstract

The roots/rhizomes of black cohosh (Actaea racemosa L. syn. Cimicifuga racemosa [L]. Nutt., Ranunculaceae) have been used traditionally by Native Americans to treat colds, rheumatism, and a variety of conditions related to women’s health. In recent years black cohosh preparations have become popular dietary supplements among women seeking alternative treatments for menopausal complaints. The popularity of the plant has led to extensive phytochemical and biological investigations, including several clinical trials. Most of the phytochemical and biological research has focused on two abundant classes of compounds: the triterpene glycosides and phenolic acids. A third group of phytoconstituents that has received far less attention consists of the alkaloids and related compounds that contain nitrogen. This chapter summarizes the current state of knowledge of the chemistry and biological activities associated with this group of constituents and provides some perspective on their significance for future research on this interesting plant.

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Authors and Affiliations

  1. UIC/NIH Center for Botanical Dietary Supplements Research, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, 833 S Wood Street, Chicago, IL, 60612-7231, USA

    Dejan Nikolić, David C. Lankin, Tamara Cisowska, Shao-Nong Chen, Guido F. Pauli & Richard B. van Breemen

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  1. Dejan Nikolić
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  2. David C. Lankin
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  3. Tamara Cisowska
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  4. Shao-Nong Chen
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    Reinhard Jetter

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Nikolić, D., Lankin, D.C., Cisowska, T., Chen, SN., Pauli, G.F., van Breemen, R.B. (2015). Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities. In: Jetter, R. (eds) The Formation, Structure and Activity of Phytochemicals. Recent Advances in Phytochemistry, vol 45. Springer, Cham. https://doi.org/10.1007/978-3-319-20397-3_2

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