Abstract
The insect cell-baculovirus protein expression vector system (BEVS) has gained increasing attention as more of its products are approved for human use. However, the system has been relevant for many years, being used for the manufacturing of recombinant veterinary vaccines, as a workhorse in the research laboratory, as an important tool for new drug discovery and as an important source of commercial materials and reagents for research. In this chapter, the key elements that should be considered for the design of a productive BEVS process are discussed, along with a presentation of the state of the art of the system.
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Acknowledgments
We are thankful to Enrique Paz for his artwork. Technical support by Rosa Román and Roberto Rodríguez. Financial support by PAPIIT UNAM IT-200113 and IT-210214.
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Palomares, L.A., Realpe, M., Ramírez, O.T. (2015). An Overview of Cell Culture Engineering for the Insect Cell-Baculovirus Expression Vector System (BEVS). In: Al-Rubeai, M. (eds) Animal Cell Culture. Cell Engineering, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-319-10320-4_15
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