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Induction and Function of Type I IFNs During Chlamydial Infection

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Bacterial Activation of Type I Interferons

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Summary

Chlamydia trachomatis is an obligate intracellular pathogen and a leading cause of sexually transmitted bacterial infection in the world. The first step in the host immune response to chlamydial infection is recognition of conserved microbial markers on Chlamydia spp. by host pathogen recognition receptors (PRRs) on epithelial cells. This innate immune recognition leads to a host inflammatory response, a major mediator of the oviduct disease during C. trachomatis genital infection. Type I IFNs are rapidly induced in response to chlamydial infection and have been shown to be bactericidal during in vitro infection. However, during in vivo infection, IFNAR signaling exacerbates oviduct pathology and is not protective to the host. This chapter summarizes the cooperative recognition of chlamydiae by the PRRs to induce type I IFNs, the downstream effect of these cytokines in pathogenesis, and the candidate chlamydial effectors initiating these responses.

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  1. Division of Pediatric Infectious Diseases, University of North Carolina at Chapel Hill, 8312 MBRB bldg., Chapel Hill, NC, USA

    Uma M. Nagarajan

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Correspondence to Uma M. Nagarajan .

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  1. Columbia University, New York, New York, USA

    Dane Parker

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Nagarajan, U.M. (2014). Induction and Function of Type I IFNs During Chlamydial Infection. In: Parker, D. (eds) Bacterial Activation of Type I Interferons. Springer, Cham. https://doi.org/10.1007/978-3-319-09498-4_9

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