Summary
Pathogenic Salmonella species reside in the phagosomes of infected cells and inject various virulence factors into the phagosome and cytoplasm of the host cell to evade the defense mechanisms. During infection of mice with Salmonella enterica serovar Typhimurium (S. typhimurium), which mimics the typhoid disease in humans, type I IFN signaling leads to rapid host fatality, and abrogation of this signaling leads to prolonged host survival. The detrimental role of type I IFN during Salmonella infection appears to be related to the modulation of inflammatory response.
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Shutinoski, B., Sad, S. (2014). The Detrimental Role of Type I Interferon Signaling During Infection with Salmonella typhimurium . In: Parker, D. (eds) Bacterial Activation of Type I Interferons. Springer, Cham. https://doi.org/10.1007/978-3-319-09498-4_7
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DOI: https://doi.org/10.1007/978-3-319-09498-4_7
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