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Polymeric Nanocarriers for Cancer Therapy

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Nano-Oncologicals

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

In the past decades, polymeric nanocarriers have emerged as a biocompatible platform for delivering therapeutic compounds to tumor sites in a cancer-selective manner, and some polymeric nanocarriers have already been approved for clinical application while more are under clinical trial, demonstrating their promises for cancer therapy. In this chapter, the concept of polymeric nanocarriers, structure design, and preparation methods are introduced and summarized firstly. Besides, the applications of polymeric nanocarriers delivering cargoes to the tumor tissues in a passive way by enhanced permeability and retention (EPR) effects and parameters that may influence this procedure have been summarized and discussed. Moreover, the polymeric nanoparticles could actively target tumor tissues through the interaction of targeting moieties on their surfaces with cancer cell-specific receptors, and several types of targeting ligands could be used for active targeting. Furthermore, polymeric nanocarriers have been functionalized to release encapsulated drugs at specific sites or time intervals controlled by environmental triggers, such as pH, temperature, and enzyme. Finally, the application of polymeric nanocarriers for primary cancer and metastatic cancer diagnosis and treatment are described. Polymeric nanocarriers have demonstrated some success in the field of cancer diagnosis and therapy, and with the progress in chemistry, biology, oncology, and modern technologies, much powerful polymeric nanocarriers would be developed for cancer therapy.

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Authors and Affiliations

  1. Polymer Chemistry Division, Chemical Resources Laboratory, Tokyo Institute of Technology, R1-11, 4259 Nagatsuta, Midori-ku, Yokohama, 226-8503, Japan

    Peng Mi & Nobuhiro Nishiyama

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  1. Peng Mi
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  2. Nobuhiro Nishiyama
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Correspondence to Peng Mi .

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  1. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, Spain

    Maria José Alonso

  2. Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago de, Compostela (IDIS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain

    Marcos Garcia-Fuentes

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Mi, P., Nishiyama, N. (2014). Polymeric Nanocarriers for Cancer Therapy. In: Alonso, M., Garcia-Fuentes, M. (eds) Nano-Oncologicals. Advances in Delivery Science and Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-08084-0_3

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