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Nano-Oncologicals

New Targeting and Delivery Approaches

  • Maria José Alonso
  • Marcos Garcia-Fuentes

Part of the Advances in Delivery Science and Technology book series (ADST)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Biological Barriers in Cancer

    1. Front Matter
      Pages 1-1
    2. Pinar Kanlikilicer, Mohammed Helmy Rashed, Bulent Ozpolat, Cristian Rodriguez-Aguayo, Anil K. Sood, George A. Calin et al.
      Pages 47-63
  3. Tumor Targeting

    1. Front Matter
      Pages 65-65
    2. Peng Mi, Nobuhiro Nishiyama
      Pages 67-94
    3. Weiyue Lu, Changyou Zhan, Huimin Hou
      Pages 95-122
    4. Claudia Conte, Francesca Ungaro, Antonino Mazzaglia, Fabiana Quaglia
      Pages 123-160
  4. Targeting the Immune System

    1. Front Matter
      Pages 161-161
    2. Javier Briones
      Pages 163-185
    3. Maria Stella Sasso, Vincenzo Bronte, Ilaria Marigo
      Pages 187-214
    4. María de la Fuente, Robert Langer, Maria José Alonso
      Pages 215-242
  5. Gene Therapy

    1. Front Matter
      Pages 243-243
    2. Katharina Müller, Ernst Wagner
      Pages 245-268
    3. Arun K. Iyer, Shanthi Ganesh, Mansoor M. Amiji
      Pages 269-291
  6. Nanotheranostics

    1. Front Matter
      Pages 293-293
    2. João Conde, Furong Tian, Pedro V. Baptista, Jesús M. de la Fuente
      Pages 295-328
    3. Tuan Pham, Carl Beigie, Yoonjee Park, Joyce Y. Wong
      Pages 329-350
    4. Amit Singh, Adwait J. Oka, Purva Pandya, Mansoor M. Amiji
      Pages 351-388
  7. Translational Aspects of Nano-Oncologicals

    1. Front Matter
      Pages 389-389
    2. Fernando Torres Andón, Bengt Fadeel
      Pages 391-424
    3. Rogério S. Gaspar, Helena F. Florindo, Liana C. Silva, Mafalda A. Videira, M. Luísa Corvo, Bárbara F. Martins et al.
      Pages 425-452
    4. Mercedes Pozuelo-Rubio, Damià Tormo Carulla, Andrés P. Gagete, María Soengas
      Pages 453-470
  8. Back Matter
    Pages 471-473

About this book

Introduction

This authoritative volume focuses on emerging technologies in cancer nanomedicine, characterized by their multi-functionality and potential to address simultaneously diverse issues of clinical relevance in the treatment of cancer. The book consists of sixteen chapters divided into six sections: 1) Biological Barriers in Cancer; 2) Tumor Targeting; 3) Targeting the Immune System; 4) Gene Therapy; 5) Nanotheranostics; and 6) Translational Aspects of Nano-Oncologicals. The volume starts with an introduction describing the biological barriers associated with cancer therapy and highlighting ways to overcome such barriers through the use of nanotechnology. This is followed by an analysis of the two major targeting strategies currently under investigation in cancer therapy: namely, the targeting of cancer cells and the targeting of the immune system. In the first case, the book presents liposomal and polymer-based therapies, including photodynamic approaches. In the second case, it analyzes in detail the possibility of either improving the efficiency of the immune system toward preventing cancer progression (cancer immunomodulation) or generating responses against specific cancer antigens (cancer vaccines).

Beyond these targeting options, Nano-Oncologicals: New Targeting and Delivery Approaches presents the most recent technological advances in the area of nucleic acid-based therapies, along with those in the area of theranostics, where the design of multifunctional nanocarriers becomes vital. Following the study of the most promising nanotechnologies around the development of nano-oncologicals, the book ends with an overview of regulatory and toxicological issues, which are critical in their translational pathway, and the presentation of a nucleic acid-based therapy case-study. This book is an important resource for scientists interested in the design and development of anticancer nanotechnologies and also to those aiming to push their technology through clinical development.

Keywords

EPR RNA delivery biomarkers liposomes nanoparticles

Editors and affiliations

  • Maria José Alonso
    • 1
  • Marcos Garcia-Fuentes
    • 2
  1. 1.Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago deCompostela (IDIS), University of Santiago de CompostelaSantiago de CompostelaSpain
  2. 2.Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Department of Pharmacy and Pharmaceutical Technology and the Health Research Institute of Santiago deCompostela (IDIS), Universidad de Santiago de CompostelaSantiago de CompostelaSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-08084-0
  • Copyright Information Controlled Release Society 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-08083-3
  • Online ISBN 978-3-319-08084-0
  • Series Print ISSN 2192-6204
  • Series Online ISSN 2192-6212
  • Buy this book on publisher's site
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