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miRNA Regulation of DNA Damage Repair Proteins in Cancer Cells: Interplay of ATM, TRAIL and miRNA

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MicroRNA Targeted Cancer Therapy

Abstract

It is becoming progressively more understandable that miRNA subsets regulate post-transcriptional processing of modulators of wide ranging cellular mechanisms. There are visible knowledge gaps related to current comprehensions about protein network that ultimately regulates decisions of DNA damage repair and apoptosis. Although evidence, in general, is sparse and fragmentary, merging knowledge links TRAIL mediated signaling, DNA damage repair and miRNA control of both of these processes as functional pathways having a key role in cell growth arrest, DNA repair and death. Methodological and technical advancements over the last decade have helped to reveal that these pathways may act in concert and there is a need to explore multiple mechanisms in parallel. Data obtained through high throughput technologies is deepening our understanding regarding miRNA regulation of DNA damage repair proteins. Moreover, confluence of information suggests that miRNAs are triggered by ATM as well as in genomically rearranged cancer cells, there is a notable alteration in expression of different miRNAs. Studies in this rapidly emerging area have started to address miRNA regulation and transportation of pre-miRNAs from nucleus to cytoplasm by ATM. Surprisingly, ATM has diametrically opposed roles in regulating TRAIL mediated apoptosis in cancer cells. In addition receptors of TRAIL had previously been reported to be regulated by ATM/p53 signaling axis. Therefore it will be interesting to study how miRNA mediated negative control of ATM influences death receptors and TRAIL mediated signaling. New technologies for identification of a larger subset of miRNA involved in modulation of regulators of DNA damage signaling and layered regulation of miRNAs by ATM and genomic rearrangements will surely help in catalyzing the transit from a segmented view of control of DNA damage repair modulators by miRNA to a conceptual continuum. Considerably improved information of these integrated pathways is essential in getting a step closer to personalized medicine.

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  1. Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, 35 Km Ferozepur Road, Lahore, Pakistan

    Ammad Ahmad Farooqi

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Correspondence to Ammad Ahmad Farooqi .

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  1. Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Fazlul H. Sarkar

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Farooqi, A.A. (2014). miRNA Regulation of DNA Damage Repair Proteins in Cancer Cells: Interplay of ATM, TRAIL and miRNA. In: Sarkar, F. (eds) MicroRNA Targeted Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-05134-5_16

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