MicroRNA Targeted Cancer Therapy

  • Fazlul H. Sarkar

Table of contents

  1. Front Matter
    Pages i-x
  2. Sanila H. Sarkar, Aamir Ahmad, Sandeep Mittal
    Pages 1-27
  3. Chaya Brodie, Efrat Buchris, Hae Kyung Lee
    Pages 29-49
  4. Zhaohui Gong, Zhuo Dong, Lihua Yang, Jie Yang, Jingqiu Li, Yanping Le et al.
    Pages 51-82
  5. Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya
    Pages 83-98
  6. Aamir Ahmad, Kevin R. Ginnebaugh, Yiwei Li, Bin Bao, Shirish M. Gadgeel, Fazlul H. Sarkar
    Pages 99-114
  7. Rong Guo, Cheryl Sherman-Baust, Kotb Abdelmohsen
    Pages 115-127
  8. Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Kanako Nakamura, Masataka Adachi et al.
    Pages 129-137
  9. Yingjie Yu, Pratima Nangia-Makker, Adhip P. N. Majumdar
    Pages 139-155
  10. Jens U. Marquardt, Peter R. Galle
    Pages 157-174
  11. Marion Gayral, Yannick Delpu, Jérôme Torrisani, Pierre Cordelier
    Pages 189-197
  12. Cesar Seigi Fuziwara, Edna Teruko Kimura
    Pages 219-237
  13. Josep Roma, Ana Almazán-Moga, José Sánchez de Toledo, Soledad Gallego, Miguel F. Segura
    Pages 239-263
  14. Hong YuWH, Daniel SzeMY, William ChoCS, YipSP
    Pages 265-287
  15. Ammad Ahmad Farooqi, Ilhan Yaylim
    Pages 309-325
  16. Ramzi M. Mohammad, B. Bao, Fazlul H. Sarkar, Philip A. Philip, Asfar S. Azmi
    Pages 327-337
  17. Back Matter
    Pages 339-351

About this book

Introduction

Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes, and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs), and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy”, and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

Keywords

Cancer Therapy Drug Resistance Solid Tumors Targeted Therapy microRNA

Editors and affiliations

  • Fazlul H. Sarkar
    • 1
  1. 1.PathologyWayne State University School of MedicineDetroitUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-319-05134-5
  • Copyright Information Springer International Publishing Switzerland 2014
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-319-05133-8
  • Online ISBN 978-3-319-05134-5
  • About this book
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