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Carbonic anhydrase inhibition in ophthalmology: Carbonic anhydrases in cornea, lens, retina and lacrimal gland

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The Carbonic Anhydrases

Part of the book series: EXS 90 ((EXS,volume 90))

Abstract

When acetazolamide and other carbonic anhydrase (CA) inhibitors were introduced in the treatment of glaucoma it was stated that they might cause side-effects from inhibition of CA in ocular tissues, where the enzyme was known to be present (Bakker, 1941). Some were also of the opinion that reduced aqueous humor flow could indirectly impair nutrition of lens, cornea and trabecular meshwork, and thus induce early cataract and corneal edema. However, after more than 40 years of therapeutic use, very few ocular side reactions have been seen after systemic long-term administration of CA inhibitors to glaucoma patients (Wistrand, 1984).

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, The University Hospital, S-751 85, Uppsala, Sweden

    Per J. Wistrand

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  1. Per J. Wistrand
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Editor information

Editors and Affiliations

  1. Lake Erie College of Osteopathic Medicine, 1858 West Grandview Boulevard, Erie, PA, 16509, USA

    W. Richard Chegwidden

  2. Medical Genetics Unit, St George’s Hospital Medical School, London, SW17 0RE, UK

    Nicholas D. Carter

  3. MRC Human Biochemical Genetics Unit, Wolfson House, University College London, 4, Stephenson Way, London, NW1 2HE, UK

    Yvonne H. Edwards

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© 2000 Springer Basel AG

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Wistrand, P.J. (2000). Carbonic anhydrase inhibition in ophthalmology: Carbonic anhydrases in cornea, lens, retina and lacrimal gland. In: Chegwidden, W.R., Carter, N.D., Edwards, Y.H. (eds) The Carbonic Anhydrases. EXS 90, vol 90. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-8446-4_20

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  • DOI: https://doi.org/10.1007/978-3-0348-8446-4_20

  • Publisher Name: Birkhäuser, Basel

  • Print ISBN: 978-3-0348-9570-5

  • Online ISBN: 978-3-0348-8446-4

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