Summary
The present paper is a survey of our work investigating opioid action on LH release, ontogeny of opioid mRNA and the development of opioid binding sites in the pig. These studies indicate that in the adult pig a) β-endorphin and leu-enkephalin may modify LH secretion independent of gonadal steroids; b) met-enkephalin inhibits LH secretion in males but not in females; and c) opioids modulate the feedback control of gonadal steroids upon LH release. Moreover, opioid action in this species seems to be age-dependent. Naloxone inhibits LH secretion in prepubertal males and females, whereas it enhances LH release in adult cyclic sows during the luteal phase.
Proenkephalin B mRNA is detectable in the brain of fetuses as early as day 34 of gestation. The pattern of development in the hippocampus differs from that in the striatum. The earliest stage at which the opioid binding sites become measurable in the fetal brain is around day 50 of gestation. A sex difference in the concentration of opioid binding sites but not proenkephalin B mRNA is apparent.
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Parvizi, N. (1988). The Ontogeny of Opioid Peptides and Their Action on LH Secretion in the Pig. In: Pawlikowski, M., Döhler, KD. (eds) Progress in Neuropeptide Research. Birkhäuser Congress Reports Life Sciences. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-5692-8_15
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DOI: https://doi.org/10.1007/978-3-0348-5692-8_15
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