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Blood Vessels

Ang-(1-7) and Vessels

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Angiotensin-(1-7)

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Abstract

This chapter focuses on the vasoprotective effects of Ang-(1-7). The vasculature is a key site of Ang-(1-7) synthesis and actions. One of the earliest functional effects described for Ang-(1-7) in the cardiovascular system was its ability to induce vasodilation. Since then, growing evidence has demonstrated multiple vasoprotective properties for Ang-(1-7) in isolated vessels, cell culture, as well as in vivo. Ang-(1-7) mediates effects through receptor Mas, a G protein-coupled receptor. In addition to its widespread vasodilatory activity, Ang-(1-7) and receptor Mas are functionally present in vascular smooth muscle cells and platelets, where Ang-(1-7) signaling through Mas induces anti-inflammatory, anti-proliferative, and antithrombotic effects. The main known vascular effects of Ang-(1-7) are described in Fig. 1.

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Authors and Affiliations

  1. University of Itaúna, Biological Sciences Institute, Itaúna, MG, Brazil

    Walyria O. Sampaio

  2. Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

    Rhian M. Touyz

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    Robson Augusto Souza Santos

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Sampaio, W.O., Touyz, R.M. (2019). Blood Vessels. In: Santos, R. (eds) Angiotensin-(1-7). Springer, Cham. https://doi.org/10.1007/978-3-030-22696-1_7

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