Skip to main content
  • Book
  • © 2019

Angiotensin-(1-7)

A Comprehensive Review

  • The first book addressing in full the most important aspects of Angiotensin-(1-7)

  • An integrative view of the modulatory biological actions of Ang-(1-7) within the renin-angiotensin system

  • Discusses the therapeutic potential of Ang-(1-7) emerging from preclinical and clinical trials

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiii
  2. Tools for Studying Angiotensin-(1-7)

    1. Front Matter

      Pages 27-27
    2. Tools for Studying Angiotensin-(1-7)

      • Robson Augusto Souza Santos
      Pages 29-34
    3. Genetic Models

      • Natalia Alenina, Michael Bader
      Pages 35-51
  3. Actions of Angiotensin-(1-7)

    1. Front Matter

      Pages 53-53
    2. Brain

      • Maria Jose Campagnole-Santos, Mariela M. Gironacci, Marco Antônio Peliky Fontes
      Pages 55-71
    3. Heart – Coronary Vessels and Cardiomyocytes

      • Anderson José Ferreira, Carlos Henrique Castro, Robson Augusto Souza Santos
      Pages 73-81
    4. Angiotensin-(1-7) and the Heart

      • Carlos M. Ferrario, Che Ping Cheng, Jasmina Varagic
      Pages 83-104
    5. Blood Vessels

      • Walyria O. Sampaio, Rhian M. Touyz
      Pages 105-116
    6. Kidney

      • Ana Cristina Simões e Silva, Robson Augusto Souza Santos
      Pages 117-130
    7. Lung

      • Giselle S. Magalhães, Maria Jose Campagnole-Santos, Maria da Glória Rodrigues-Machado
      Pages 131-152
    8. Angiotensin-(1-7): Role in the Endocrine System

      • Sérgio Henrique Sousa Santos
      Pages 153-168
    9. Skeletal Muscle System

      • María José Acuña, Enrique Brandan, Daisy Motta-Santos
      Pages 169-190
    10. Liver

      • Aline Silva de Miranda, Ana Cristina Simões e Silva
      Pages 191-199
    11. Angiotensin 1-7 and Inflammation

      • Izabela Galvão, Flavia Rago, Isabella Zaidan Moreira, Mauro Martins Teixeira
      Pages 201-218
    12. The Role of Angiotensin–(1-7) in Cancer

      • Ana Cristina Simões e Silva, Walkyria O. Sampaio
      Pages 219-229
    13. Concluding Remarks

      • Robson Augusto Souza Santos
      Pages 231-233
  4. Back Matter

    Pages 235-240

About this book

This is the first book addressing in full the most important aspects of the angiotensin-(1-7), the key peptide of the protective axis and the main component in the new modulatory concept of the renin-angiotensin system. It features a detailed review of angiotensin-(1-7) and its receptor Mas, comprising the historical background, enzymatic pathways for generation, functions, integrative aspects of its protective profile, and its therapeutic potential. It also encompasses a comprehensive presentation of current knowledge about its widespread biological actions on several tissues, as well as the most recent scientific achievements, emerging from preclinical and clinical trials. 


Dr. Santos is a renowned researcher on the Renin-Angiontensin system, with remarkable achievements regarding the role of peptides such as alamandine and angiontensin-(1-7). He has also worked on the potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field, including the publication of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015).

Angiotensin-(1-7) will make a unique contribution to the literature and will be an important resource for biomedical students and researchers, medical practitioners and any other professional interested in this peptide and its role in the renin-angiotensin system.


Editors and Affiliations

  • Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    Robson Augusto Souza Santos

About the editor

Dr. Santos obtained his medical degree from the Medical School of Itajuba (1976), a master's degree in Biological Sciences (Physiology and Pharmacology) from the Federal University of Minas Gerais (1979) and a PhD in Physiology from the University of São Paulo (1983). He completed his postdoc at the Cleveland Clinic Foundation from 1986 to 1989. He is currently emeritus professor at the Federal University of Minas Gerais and the coordinator of INCT-NanoBiofar (National Institute for NanoBiopharmaceutics). He has experience in physiology with emphasis in cardiovascular physiology. His main works are related to the following topics: Angiotensin-(1-7), angiotensin II, hypertension, and the renin-angiotensin system. His research also includes potential clinical applicability of angiotensin-(1-7)-related drugs for cardiovascular diseases. He has an extensive publication record in the field and is co-author of the book The Protective Arm of the Renin Angiotensin System (Academic Press, 2015).


Bibliographic Information

  • Book Title: Angiotensin-(1-7)

  • Book Subtitle: A Comprehensive Review

  • Editors: Robson Augusto Souza Santos

  • DOI: https://doi.org/10.1007/978-3-030-22696-1

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-22695-4Published: 02 September 2019

  • Softcover ISBN: 978-3-030-22698-5Published: 02 September 2020

  • eBook ISBN: 978-3-030-22696-1Published: 21 August 2019

  • Edition Number: 1

  • Number of Pages: XIII, 240

  • Number of Illustrations: 10 b/w illustrations, 23 illustrations in colour

  • Topics: Cardiology, Human Physiology

  • Industry Sectors: Biotechnology, Engineering, Finance, Business & Banking, Health & Hospitals, Pharma

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access