Skip to main content

Should Level IIb Be Addressed Routinely in Clinically Node Negative Oral Cancers?

  • Chapter
  • First Online:
Difficult Decisions in Head and Neck Oncologic Surgery

Part of the book series: Difficult Decisions in Surgery: An Evidence-Based Approach ((DDSURGERY))

  • 613 Accesses

Abstract

A conundrum commonly faced by any Head and Neck surgeon is whether to address level IIb in patients with clinically node negative oral cancer. A thorough literature search was conducted evaluating the occult metastasis at level IIb in cN0 neck in oral cavity cancer patients and to assess whether level IIb dissection actually affected the spinal accessory nerve function. Based upon the review we found that occult metastasis at level IIb can occur in oral cavity carcinoma regardless of T stage. These may occur more often in patients with tongue cancer. Though some degree of accessory nerve dysfunction may occur following IIb dissection, it has not been proven to be of clinical relevance.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Robbins KT, Medina JE, Wolfe GT, Levine PA, Sessions RB, Pruet CW. Standardizing neck dissection terminology. Official report of the Academy’s Committee for Head and Neck Surgery and Oncology. Arch Otolaryngol Head Neck Surg. 1991;117(6):601–5.

    Article  CAS  Google Scholar 

  2. Robbins KT, Clayman G, Levine PA, Medina J, Sessions R, Shaha A, Som P, Wolf GT. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Head Neck Surg. 2002;128(7):751–8.

    Article  Google Scholar 

  3. Robbins KT, Shaha AR, Medina JE, Califano JA, Wolf GT, Ferlito A, Som PM, Day TA. Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Head Neck Surg. 2008;134(5):536–8. https://doi.org/10.1001/archotol.134.5.536.

    Article  PubMed  Google Scholar 

  4. D’Cruz AK, et al. Elective versus therapeutic neck dissection in node-negative oral cancer. N Engl J Med. 2015;373(6):521–9. https://doi.org/10.1056/NEJMoa1506007. Epub 2015 May 31.

    Article  CAS  PubMed  Google Scholar 

  5. Lea J, Bachar G, Sawka AM, Lakra DC, Gilbert RW, Irish JC, Brown DH, Gullane PJ, Goldstein DP. Metastases to level IIb in squamous cell carcinoma of the oral cavity: a systematic review and meta-analysis. Head Neck. 2010;32(2):184–90. https://doi.org/10.1002/hed.21163.

    Article  PubMed  Google Scholar 

  6. Kou Y, Zhao T, Huang S, Liu J, Duan W, Wang Y, Wang Z, Li D, Ning C, Sun C. Cervical level IIb metastases in squamous cell carcinoma of the oral cavity: a systematic review and meta-analysis. Onco Targets Ther. 2017;10:4475–83. https://doi.org/10.2147/OTT.S143392. eCollection 2017.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Paleri V, Kumar Subramaniam S, Oozeer N, Rees G, Krishnan S. Dissection of the submuscular recess (sublevel IIb) in squamous cell cancer of the upper aerodigestive tract: prospective study and systematic review of the literature. Head Neck. 2008;30(2):194–200.

    Article  Google Scholar 

  8. Lim YC, Song MH, Kim SC, Kim KM, Choi EC. Preserving level IIb lymph nodes in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004;130(9):1088–91.

    Article  Google Scholar 

  9. Maher NG, Hoffman GR. Elective neck dissection for primary oral cavity squamous cell carcinoma involving the tongue should include sublevel IIb. J Oral Maxillofac Surg. 2014;72(11):2333–43.

    Article  Google Scholar 

  10. Agarwal SK, Arora SK, Kumar G, Sarin D. Isolated perifacial lymph node metastasis in oral squamous cell carcinoma with clinically node-negative neck. Laryngoscope. 2016;126(10):2252–6.

    Article  CAS  Google Scholar 

  11. Elsheikh M, Mahfouz M, Elsheikh E. Level IIb lymph node metastases in elective supraomohyoid neck dissection for oral cavity squamous cell carcinoma: a molecular-based study. Laryngoscope. 2005;115:1636–40.

    Article  Google Scholar 

  12. Chiesa F, Mauri S, Grana C, et al. Is there a role for sentinel node biopsy in early N0 tongue tumors? Surgery. 2000;128:16–21.

    Article  CAS  Google Scholar 

  13. Kraus D, Rosenberg D, Davidson B, et al. Supraspinal accessory lymph node metastases in supraomohyoid neck dissection. Am J Surg. 1996;172:646–9.

    Article  CAS  Google Scholar 

  14. Dabholkar J, Kapre N. Level IIb neck dissection in oral cavity cancers—when should one address it? Indian J Surg Oncol. 2016;7(3):303–6. https://doi.org/10.1007/s13193-015-0461-5.

    Article  PubMed  Google Scholar 

  15. Corlette TH, Cole IE, Albsoul N, Ayyash M. Neck dissection of level IIb: is it really necessary? Laryngoscope. 2005;115(9):1624–6.

    Article  Google Scholar 

  16. Manola M, Aversa C, Moscillo L, Villano S, Pavone E, Cavallo C, Mastella A, Ionna F. Status of level IIb lymph nodes of the neck in squamous cell carcinoma of the oral tongue in patients who underwent modified radical neck dissection and lymph node sentinel biopsy. Acta Otorhinolaryngol Ital. 2011;31(3):130–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Talmi YP, Hoffman HT, Horowitz Z, McCulloch TM, Funk GF, Graham SM, Peleg M, Yahalom R. Patterns of metastases to the upper jugular lymph nodes (the “submuscular recess”). Head Neck. 1998;20(8):682–6.

    Article  CAS  Google Scholar 

  18. Pantvaidya GH, Pal P, Vaidya AD, Pai PS, D'Cruz AK. Prospective study of 583 neck dissections in oral cancers: implications for clinical practice. Head Neck. 2014;36(10):1503–7.

    PubMed  Google Scholar 

  19. Nahum A, Mullally W, Marmor L. A syndrome resulting from radical neck dissection. Arch Otolaryngol. 1961;74:424–8.

    Article  CAS  Google Scholar 

  20. Ewing M, Martin H. Disability following “radical neck dissection”. Cancer. 1952;5:873–83.

    Article  CAS  Google Scholar 

  21. Dijkstra PU, van Wilgen PC, Buijs RP, Brendeke W, de Goede CJ, Kerst A, et al. Incidence of shoulder pain after neck dissection: a clinical explorative study for risk factors. Head Neck. 2001;23:947–53.

    Article  CAS  Google Scholar 

  22. Cheng PT, Hao SP, Lin YH, Yeh AR. Objective comparison of shoulder dysfunction after three neck dissection techniques. Ann Otol Rhinol Laryngol. 2000;109:761–6.

    Article  CAS  Google Scholar 

  23. Cappiello J, Piazza C, Giudice M, De Maria G, Nicolai P. Shoulder disability after different selective neck dissections (levels II–IV versus levels II–V): a comparative study. Laryngoscope. 2005;115:259–63.

    Article  Google Scholar 

  24. Köybasioglu A, Tokcaer AB, Uslu S, Ileri F, Beder L, Ozbilen S. Accessory nerve function after modified radical and lateral neck dissections. Laryngoscope. 2000;110:73–7.

    Article  Google Scholar 

  25. Koybaşioğlu A, Bora Tokçaer A, Inal E, Uslu S, Koçak T, Ural A. Accessory nerve function in lateral selective neck dissection with undissected level IIb. ORL J Otorhinolaryngol Relat Spec. 2006;68(2):88–92. Epub 2006 Jan 27.

    Article  Google Scholar 

  26. Pinsolle V, Michelet V, Majoufre C, Caix P, Siberchicot F, Pinsolle J. Spinal accessory nerve and lymphatic neck dissection. Rev Stomatol Chir Maxillofac. 1997;98(3):138–42.

    CAS  PubMed  Google Scholar 

  27. Orhan KS, Demirel T, Baslo B, Orhan EK, Yücel EA, Güldiken Y, et al. Spinal accessory nerve function after neck dissections. J Laryngol Otol. 2007;121:44–8.

    Article  CAS  Google Scholar 

  28. Cappiello J, Cesare P, Nicolai P. The spinal accessory nerve in head and neck surgery. Curr Opin Otolaryngol Head Neck Surg. 2007;15:107–11.

    Article  Google Scholar 

  29. Tsuji T, Tanuma A, Onitsuka T, Ebihara M, Iida Y, Kimura A, et al. Electromyography findings after different selective neck dissections. Laryngoscope. 2007;117:319–22.

    Article  Google Scholar 

  30. Selcuk A, Selcuk B, Bahar S, Dere H. Shoulder function in various types of neck dissection. Role of spinal accessory nerve and cervical plexus preservation. Tumori. 2008;94(1):36–9.

    Article  Google Scholar 

  31. Inoue H, Nibu K, Saito M, Otsuki N, Ishida H, Onitsuka T, et al. Quality of life after neck dissection. Arch Otolaryngol Head Neck Surg. 2006;132(6):662–6.

    Article  Google Scholar 

  32. Patten C, Hillel AD. The 11th nerve syndrome. Accessory nerve palsy or adhesive capsulitis? Arch Otolaryngol Head Neck Surg. 1993;119:215–20.

    Article  CAS  Google Scholar 

  33. Eisele DW, Weymuller EA Jr, Price JC. Spinal accessory nerve preservation during neck dissection. Laryngoscope. 1991;101:433–5.

    Article  CAS  Google Scholar 

  34. Lima LP, Amar A, Lehn CN. Spinal accessory nerve neuropathy following neck dissection. Braz J Otorhinolaryngol. 2011;77(2):259–62.

    Article  Google Scholar 

  35. Giordano L, Sarandria D, Fabiano B, Del Carro U, Bussi M. Shoulder function after selective and superselective neck dissections: clinical and functional outcomes. Acta Otorhinolaryngol Ital. 2012;32(6):376–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Celik B, Coskun H, Kumas FF, Irdesel J, Zarifoglu M, Erisen L, Onart S. Accessory nerve function after level 2b-preserving selective neck dissection. Head Neck. 2009;31(11):1496–501. https://doi.org/10.1002/hed.21112.

    Article  PubMed  Google Scholar 

  37. Parikh S, Tedman B, Scott B, et al. A double blind randomised trial of IIb or not IIb neck dissections on electromyography, clinical examination, and questionnaire-based outcomes: a feasibility study. Br J Oral Maxillofac Surg. 2012;50:394.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Chaturvedi, P., Malik, A. (2019). Should Level IIb Be Addressed Routinely in Clinically Node Negative Oral Cancers?. In: Gooi, Z., Agrawal, N. (eds) Difficult Decisions in Head and Neck Oncologic Surgery. Difficult Decisions in Surgery: An Evidence-Based Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-15123-2_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-15123-2_5

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-15122-5

  • Online ISBN: 978-3-030-15123-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics