Epidemiology of Central Nervous System Fungal Infections

  • Sanjeet Singh DadwalEmail author


Invasive fungal infection (IFI) of the central nervous system (CNS) leads to significant morbidity and mortality. The clinical presentation of CNS IFI is highly variable, leading to a delay in diagnosis. The burden of IFI has been increasing with the increasing numbers of at-risk population, opportunistic fungi in the immunocompromised patients with disseminated disease, post-neurosurgical procedures, implantable devices, spread from contiguous site (sinuses), and environmental exposures in the context of endemic fungi. However, an accurate measure of the CNS disease burden is not known with the exception of cryptococcal infection. The spectrum of the CNS IFI ranges from meningitis and meningoencephalitis to the parenchymal involvement with brain abscesses.


Central nervous system Invasive fungal infection Epidemiology Meningitis Brain abscess 



Caspase recruitment domain-containing protein 9 deficiency


Chronic granulomatous disease


Central nervous system


Graft-versus-host disease


Hematopoietic cell transplantation


Human immunodeficiency virus/acquired immunodeficiency syndrome


Intensive care unit


Invasive fungal infection


Solid organ transplantation


Tumor necrosis factor-alpha


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Infectious DiseaseCity of Hope National Medical CenterDuarteUSA

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