Cladophialophora bantiana

  • Hurriyet Deniz Ozgun
  • Darren L. Jacobs
  • Steven A. TomsEmail author


Cladophialophora bantiana is a thermotolerant multinucleated saprophytic black mold that reproduces asexually via unicellular conidia. Melanin present in C. bantiana is a potential virulence factor for the pathogenesis of central nervous system infections and is the reason behind the darkly pigmented appearance, which gives a specific name to its infection: phaeohyphomycosis, meaning “of dark hyphal fungus.” Overall, 48% of the cerebral phaeohyphomycosis cases reported were caused by C. bantiana, with a mortality of 71%. Prolonged treatment with antifungal medicine, especially when combined with newer antifungals, can give more promising results. Even when complete resection and long-term antifungal treatment suggest resolution, infections with C. bantiana should be followed up for 1–2 years after apparent resolution to avoid relapse.


Melanin CNS infection Black mold Fungus Brain abscess 



Amplified fragment length polymorphism


Central nervous system


Computed tomography


Cerebrospinal fluid






Internal transcribed spacer


Magnetic resonance imaging


Polymerase chain reaction




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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Hurriyet Deniz Ozgun
    • 1
    • 2
  • Darren L. Jacobs
    • 3
  • Steven A. Toms
    • 2
    • 4
    Email author
  1. 1.Acıbadem Mehmet Ali Aydınlar UniversityİstanbulTurkey
  2. 2.Department of NeurosurgeryLifespan Health SystemProvidenceUSA
  3. 3.Department of NeurosurgeryGeisinger Health SystemDanvilleUSA
  4. 4.Brown University Alpert Medical SchoolProvidenceUSA

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