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Conclusions and Future Possibilities: IORT

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Long-term experience has shown that the use of IORT as a component of treatment in conjunction with other modalities (EBRT, concurrent and maintenance chemotherapy, maximal surgical resection) is feasible and practical if close multidisciplinary cooperation exists. IORT-containing, multimodality regimens appear to improve local disease control, if not survival, in many disease sites when compared with non-IORT treatment approaches. For patients in whom gross total resection of their cancer is not safely feasible, however, the ability to achieve central or local control is lessened, thus creating the need for prospective clinical trials that address the addition of radiation dose modifiers during both EBRT and IORT. Patients with locally advanced or locally recurrent cancers who are candidates for IORT-containing regimens often have high systemic risks as well. Prospective trials will also be necessary that address the addition of aggressive systemic therapy to the locally aggressive combined treatment.

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Authors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic College of Medicine and Mayo Clinic Arizona, Scottsdale, AZ, USA

    Leonard L. Gunderson

  2. Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA

    Christopher G. Willett

  3. Department of Oncology, Hospital Gregorio Maranon, 28007, Madrid, Spain

    Felipe A. Calvo

  4. Department of Radiation Oncology, Continuum Cancer Centers of New York, Beth Israel Medical Center, St Luke’s and Roosevelt Hospitals, Albert Einstein College of Medicine, New York, NY, USA

    Louis B. Harrison

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  1. Leonard L. Gunderson
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  4. Louis B. Harrison
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Correspondence to Leonard L. Gunderson .

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Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Gunderson, L.L., Willett, C.G., Calvo, F.A., Harrison, L.B. (2011). Conclusions and Future Possibilities: IORT. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_23

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