Intraoperative Irradiation

Techniques and Results

  • Leonard L. Gunderson
  • Christopher G. Willett
  • Felipe A. Calvo
  • Louis B. Harrison

Part of the Current Clinical Oncology book series (CCO)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. General Rationale and Historical Perspective

    1. Front Matter
      Pages 1-1
    2. Leonard L. Gunderson, Felipe A. Calvo, Christopher G. Willett, Louis B. Harrison
      Pages 3-26
    3. Paul Okunieff, Srinath Sundararaman, Su Metcalfe, Yuhchyau Chen
      Pages 27-47
  3. Methods and Techniques of Treatment

    1. Front Matter
      Pages 49-49
    2. Peter Biggs, Christopher G. Willett, Harm Rutten, Mario Ciocca, Leonard L. Gunderson, Felipe A. Calvo
      Pages 51-72
    3. Eli E. Furhang, Jussi K. Sillanpaa, Kenneth S. Hu, Louis B. Harrison
      Pages 73-84
    4. Uta Kraus-Tiefenbacher, Peter Biggs, Jayant Vaidya, Dario Francescatti
      Pages 85-98
    5. Subir Nag, Christopher G. Willett, Leonard L. Gunderson, Louis B. Harrison, Felipe A. Calvo, Peter Biggs
      Pages 99-115
  4. Normal Tissue Tolerance: IORT

    1. Front Matter
      Pages 117-117
    2. Zeljko Vujaskovic, Christopher G. Willett, Joel E. Tepper, Timothy J. Kinsella, Leonard L. Gunderson
      Pages 119-138
  5. Results of IORT Alone or Plus EBRT by Disease Site

    1. Front Matter
      Pages 139-139
    2. David Ortiz de Urbina, Patrick Schueller, Normann Willich, Kintomo Takakura, Osami Kubo, Felipe A. Calvo
      Pages 141-161
    3. Kenneth S. Hu, Sue Yom, Michael J. Kaplan, Rafael Martinez-Monge, Louis B. Harrison
      Pages 163-188
    4. Felix Sedlmayer, Jean-Bernard DuBois, Roland Reitsamer, Gerd Fastner, David Olilla, Roberto Orecchia
      Pages 189-200
    5. Javier Aristu, Felipe A. Calvo, Marta Moreno, Rafael Martínez, Jesús Herreros, María Esperanza Rodriguez et al.
      Pages 201-222
    6. Rafael Martinez-Monge, Miren Gaztañaga, Javier Álvarez-Cienfuegos, Robert C. Miller, Felipe A. Calvo
      Pages 223-248
    7. Robert C. Miller, Vincenzo Valentini, Adyr Moss, Giuseppe R. D’Agostino, Matthew D. Callister, Theodore S. Hong et al.
      Pages 249-271
    8. Takeshi Todoroki, Gernot M. Kaiser, Wolfgang Sauerwein, Leonard L. Gunderson
      Pages 273-295
    9. Nils D. Arvold, Theodore S. Hong, Christopher G. Willett, Paul C. Shellito, Michael G. Haddock, Harm Rutten et al.
      Pages 297-322
    10. Michael G. Haddock, Heidi Nelson, Vincenzo Valentini, Leonard L. Gunderson, Christopher G. Willett, Harm Rutten et al.
      Pages 323-351
    11. Brian Czito, John Donohue, Christopher G. Willett, Douglas Tyler, Ivy A. Petersen, Robert Krempien et al.
      Pages 353-386
    12. Ivy A. Petersen, Robert Krempien, Christopher Beauchamp, Michael Eble, Felipe A. Calvo, Ignacio Azinovic et al.
      Pages 387-405
    13. Felipe A. Calvo, Luis Sierrasesumaga, Ana Patiño, Carmen González, Manuel González, Carlos Ferrer et al.
      Pages 407-429
    14. Kaled M. Alektiar, Michael G. Haddock, Dennis Chi, Felipe A. Calvo, Ivy A. Petersen
      Pages 431-457
    15. Marco Krengli, Felipe A. Calvo, Carlo Terrone, Michael G. Haddock, Jean-Michel Hannoun-Levi, Juliette Thariat et al.
      Pages 459-479
    16. Nadia N. Issa Laack, Paula J. Schomberg, Suzanne Wolden, Jesus Vazquez
      Pages 481-500
  6. Conclusions and Future Possibilities

    1. Front Matter
      Pages 501-501
    2. Leonard L. Gunderson, Christopher G. Willett, Felipe A. Calvo, Louis B. Harrison
      Pages 503-518
  7. Back Matter
    Pages 519-529

About this book


The rationale for using intraoperative irradiation (IORT) is based on the realization that tolerable doses of eternal beam radiation are often insufficient to achieve control of locally advanced malignancies. In these instances, the IORT component of treatment becomes the optimal conformal technique of irradiation, since dose-limiting organs or structures can either be surgically displaced or protected by placement of lead shielding.

This fully revised and expanded second edition is of interest to those with intraoperative electron (IOERT) capabilities, high-dose-rate brachytherapy (HDR-IORT) capabilities, or both. Techniques, indications, and results are discussed by disease site. Each chapter is dual authored by a radiation oncologist and a surgeon, giving a balanced presentation of clinical scenarios. Issues of basic science and physics are also covered, and a notable chapter on normal tissue tolerance is included.

Intraoperative Irradiation: Techniques and Results, Second Edition is a superb compilation, providing essential cutting-edge knowledge. It is a foundation for physicians as IORT develops and becomes more widely available.

Editors and affiliations

  • Leonard L. Gunderson
    • 1
  • Christopher G. Willett
    • 2
  • Felipe A. Calvo
    • 3
  • Louis B. Harrison
    • 4
  1. 1.Department of Radiation OncologyMayo ClinicScottsdaleUSA
  2. 2.Dept. Radiation OncologyDuke University Medical CenterDurhamUSA
  3. 3.Gregorio Marañón, Depto. Radiación de OncologíaHospital General UniversitarioMadridSpain
  4. 4.Albert Einstein College of Medicine, Radiation OncologyBeth Israel Medical CenterNew YorkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Humana Press
  • eBook Packages Medicine
  • Print ISBN 978-1-61779-014-0
  • Online ISBN 978-1-61779-015-7
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals