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Recurrent Colorectal Cancer

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

Aggressive, curative intent treatment approaches in patients with local or regional relapse after resection of primary rectal or colon cancers are often not considered. A growing body of evidence supports an aggressive approach combining external beam irradiation (EBRT)  ±  chemotherapy, resection, and intraoperative irradiation (IORT) in conjunction with systemic chemotherapy. Data will be presented in this chapter summarizing disease control and survival results with IORT-containing regimens from US and European institutions including the impact of prognostic factors on results and the results in previously irradiated patients. IORT tolerance and future potential as a component of treatment will be discussed.

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Authors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA

    Michael G. Haddock

  2. Department of Colorectal Surgery, Mayo Clinic, Rochester, MN, USA

    Heidi Nelson

  3. Radiation Oncology, Polyclinico Universitario A. Gemelli, Rome, Italy

    Vincenzo Valentini

  4. Department of Radiation Oncology, Mayo Clinic College of Medicine and Mayo Clinic Arizona, Scottsdale, AZ, USA

    Leonard L. Gunderson

  5. Radiation Oncology, Duke University, Durham, NC, 27710, USA

    Christopher G. Willett

  6. Colorectal Surgery, Catharina Hospital, Eindhoven, the Netherlands

    Harm Rutten

  7. Radiation Oncology, Hospital Gregorio Maranon, Madrid, Spain

    Felipe A. Calvo

  8. Department of Radiation Oncology, Continuum Cancer Centers of New York, Beth Israel Medical Center, St Luke’s and Roosevelt Hospitals, Albert Einstein College of Medicine, New York, NY, USA

    Louis B. Harrison

  9. Surgical Oncology, Beth Israel, New York, NY, 10003, USA

    Warren Enker

  10. Surgical Oncology, Hospital Gregorio Maranon, Madrid, 28007, Spain

    J. L. Garcia-Sabrido

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  1. Michael G. Haddock
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  2. Heidi Nelson
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  7. Felipe A. Calvo
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  10. J. L. Garcia-Sabrido
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Correspondence to Michael G. Haddock .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Haddock, M.G. et al. (2011). Recurrent Colorectal Cancer. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_16

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  • DOI: https://doi.org/10.1007/978-1-61779-015-7_16

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