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Gastric Cancer

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Intraoperative Irradiation

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

Gastric cancer has experienced a marked change in prevalence during the last few decades. While in some countries, as in the Far East, gastric cancer continues to be a national health problem, the incidence in most Western countries has experienced a significant decline in both sexes. The causes of this decline are unknown [1]. Most importantly, while the overall incidence of gastric cancer has decreased in Europe and USA, there has been an increase in the relative percentage of proximal gastric adenocarcinomas (ACA) and ACA arising in the gastroesophageal junction (GEJ), especially in white males. With the exception of Japan, where mass screening programs have increased the number of patients diagnosed of early gastric cancer, diagnosis at an advanced stage is the rule. Approximately 50–75% of the patients who have gastric resection for cancer have serosal invasion and/or lymph node involvement. This helps to explain why cure rates have remained unchanged for decades in spite of improvements in oncologic therapy. Investigators should consider that both accrual and design of future trials in gastric cancer will probably be affected by these epidemiological trends.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Navarra University Clinic, Pamplona, Spain

    Rafael Martinez-Monge & Miren Gaztañaga

  2. Department of Surgery, Navarra University Clinic, Pamplona, Spain

    Javier Álvarez-Cienfuegos

  3. Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA

    Robert C. Miller

  4. Department of Radiation Oncology, University Hospital Gregorio Maranon, Madrid, Spain

    Felipe A. Calvo

Authors
  1. Rafael Martinez-Monge
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  2. Miren Gaztañaga
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  3. Javier Álvarez-Cienfuegos
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  4. Robert C. Miller
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  5. Felipe A. Calvo
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Corresponding author

Correspondence to Rafael Martinez-Monge .

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic, East Shea Blvd 13400, Scottsdale, 85259, Arizona, USA

    Leonard L. Gunderson

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA

    Christopher G. Willett

  3. Gregorio Marañón, Depto. Radiación de Oncología, Hospital General Universitario, C/ Dr. Esquerdo 46, Madrid, 28007, Spain

    Felipe A. Calvo

  4. Albert Einstein College of Medicine, Radiation Oncology, Beth Israel Medical Center, Union Square East 10, New York, 10003, New York, USA

    Louis B. Harrison

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Martinez-Monge, R., Gaztañaga, M., Álvarez-Cienfuegos, J., Miller, R.C., Calvo, F.A. (2011). Gastric Cancer. In: Gunderson, L., Willett, C., Calvo, F., Harrison, L. (eds) Intraoperative Irradiation. Current Clinical Oncology. Humana Press. https://doi.org/10.1007/978-1-61779-015-7_12

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  • DOI: https://doi.org/10.1007/978-1-61779-015-7_12

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