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Quality-of-Life Issues Posttransplantation

  • Chapter
Stem Cell Transplantation for Hematologic Malignancies

Part of the book series: Contemporary Hematology ((CH))

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Abstract

Quality of life (QOL) refers to every dimension of life except for its length, and it includes physical abilities, symptoms, social well-being, psychoemotional status, and spiritual/existential qualities. It reflects how well people feel, what they can accomplish, how satisfied they are with their lives, and whether their lives have meaning and purpose. Within this broad concept, health-related quality of life (HR-QOL) refers to aspects of QOL that are attributable to health, disease, or medical treatment. (In this chapter, the abbreviation QOL is used for simplicity.) Following hematopoietic stem cell transplantation (HSCT), QOL can range from perfect, with no physical, emotional, or social sequelae and a greater appreciation for life, to severely compromised, with physical disability, pain, and psychological despair. Of course, most patients who have undergone HSCT fall within this spectrum. The goal of this chapter is to provide an overview of concepts and published work rather than review individual studies exhaustively. Additional sections address how to evaluate QOL studies and use QOL data in the care of individual patients.

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References

  1. Grant M. Assessment of quality of life following hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoetic Cell Transplantation. Malden, UK: Blackwell Sciences, 1999: 407–413.

    Google Scholar 

  2. Slevin ML, Plant H, Lynch D, et al. Who should measure quality of life, the doctor or the patient? Br J Cancer 1988; 57: 109–112.

    Article  PubMed  CAS  Google Scholar 

  3. King CR, Ferrell BR, Grant M, et al. Nurses’ perceptions of the meaning of quality of life for bone marrow transplant survivors. Cancer Nurs 1995; 18: 118–129.

    Article  PubMed  CAS  Google Scholar 

  4. Ferrell B, Grant M, Schmidt GM, et al. The meaning of quality of life for bone marrow transplant survivors. Part 1. The impact of bone marrow transplant on quality of life. Cancer Nurs 1992; 15: 153–160.

    PubMed  CAS  Google Scholar 

  5. Ferrell B, Grant M, Schmidt GM, et al. The meaning of quality of life for bone marrow transplant survivors. Part 2. Improving quality of life for bone marrow transplant survivors. Cancer Nurs 1992; 15: 247–253.

    PubMed  CAS  Google Scholar 

  6. Haberman M, Bush N, Young K, et al. Quality of life of adult long-term survivors of bone marrow transplantation: a qualitative analysis of narrative data. Oncol Nurs Forum 1993; 20: 1545–1553.

    PubMed  CAS  Google Scholar 

  7. Baker F, Zabora J, Polland A, et al. Reintegration after bone marrow transplantation. Cancer Pract 1999; 7: 190–197.

    Article  PubMed  CAS  Google Scholar 

  8. Altmaier EM, Gingrich RD, Fyfe MA. Two-year adjustment of bone marrow transplant survivors. Bone Marrow Transplant 1991; 7: 311–316.

    PubMed  CAS  Google Scholar 

  9. Baker F, Wingard JR, Curbow B, et al. Quality of life of bone marrow transplant long-term survivors. Bone Marrow Transplant 1994; 13: 589–596.

    PubMed  CAS  Google Scholar 

  10. Andrykowski MA. Psychosocial factors in bone marrow transplantation: a review and recommendations for research. Bone Marrow Transplant 1994; 13: 357–375.

    PubMed  CAS  Google Scholar 

  11. Bush NE, Haberman M, Donaldson G, et al. Quality of life of 125 adults surviving 6–18 years after bone marrow transplantation. Soc Sci Med 1995; 40: 479–490.

    Article  PubMed  CAS  Google Scholar 

  12. Sutherland HJ, Fyles GM, Adams G, et al. Quality of life following bone marrow transplantation: a comparison of patient reports with population norms. Bone Marrow Transplant 1997; 19: 1129–1136.

    Article  PubMed  CAS  Google Scholar 

  13. Kiss TL, Abdolell M, Jamal N, et al. Long-term medical outcomes and quality-of-life assessment of patients with chronic myeloid leukemia followed at least 10 years after allogeneic bone marrow transplantation. J Clin Oncol 2002; 20: 2334–2343.

    Article  PubMed  CAS  Google Scholar 

  14. Syrjala KL, Chapko MK, Vitaliano PP, et al. Recovery after allogeneic marrow transplantation: prospective study of predictors of long-term physical and psychosocial functioning. Bone Marrow Transplant 1993; 11: 319–327.

    PubMed  CAS  Google Scholar 

  15. Belec RH. Quality of life: perceptions of long-term survivors of bone marrow transplantation. Oncol Nurs Forum 1992; 19: 31–37.

    PubMed  CAS  Google Scholar 

  16. Andrykowski MA, Brady MJ, Greiner CB, et al. “Returning to normal” following bone marrow transplantation: outcomes, expectations and informed consent. Bone Marrow Transplant 1995; 15: 573–581.

    PubMed  CAS  Google Scholar 

  17. McQuellon RP, Russell GB, Rambo TD, et al. Quality of life and psychological distress of bone marrow transplant recipients: the “time trajectory” to recovery over the first year. Bone Marrow Transplant 1998; 21: 477–486.

    Article  PubMed  CAS  Google Scholar 

  18. Zittoun R, Suciu S, Watson M, et al. Quality of life in patients with acute myelogenous leukemia in prolonged first complete remission after bone marrow transplantation (allogeneic or autologous) or chemotherapy: a cross-sectional study of the EORTC-GIMEMA AML 8A trial. Bone Marrow Transplant 1997; 20: 307–315.

    Article  PubMed  CAS  Google Scholar 

  19. Hjermstad M, Holte H, Evensen S, et al. Do patients who are treated with stem cell transplantation have a health-related quality of life comparable to the general population after 1 year? Bone Marrow Transplant 1999; 24: 911–918.

    Article  PubMed  CAS  Google Scholar 

  20. Heinonen H, Volin L, Uutela A, et al. Quality of life and factors related to perceived satisfaction with quality of life after allogeneic bone marrow transplantation. Ann Hematol 2001; 80: 137–143.

    Article  PubMed  CAS  Google Scholar 

  21. Neitzert CS, Ritvo P, Dancey J, et al. The psychosocial impact of bone marrow transplantation: a review of the literature. Bone Marrow Transplant 1998; 22: 409–422.

    Article  PubMed  CAS  Google Scholar 

  22. McQuellon RP, Andrykowski MA. Psychosocial complications of hematopoietic stem cell transplantation. In: Atkinson K, ed. Clinical Bone Marrow and Blood Stem Cell Transplantation. Cambridge: Cambridge University Press, 2000: 1045–1054.

    Google Scholar 

  23. Schimmer AD, Elliott ME, Abbey SE, et al. Illness intrusiveness among survivors of autologous blood and marrow transplantation. Cancer 2001; 92: 3147–3154.

    Article  PubMed  CAS  Google Scholar 

  24. Smith MY, Redd W, DuHamel K, Vickberg SJ, Ricketts P. Validation of the PTSD Checklist-Civilian Version in survivors of bone marrow transplantation. J Trauma Stress 1999; 12: 485–499.

    Article  PubMed  CAS  Google Scholar 

  25. Widows MR, Jacobsen PB, Fields KK. Relation of psychological vulnerability factors to posttraumatic stress disorder symptomatology in bone marrow transplant recipients. Psychosom Med 2000; 62: 873–882.

    PubMed  CAS  Google Scholar 

  26. Fife BL, Huster GA, Cornetta KG, et al. Longitudinal study of adaptation to the stress of bone marrow transplantation. J Clin Oncol 2000; 18: 1539–1549.

    PubMed  CAS  Google Scholar 

  27. Prieto JM, Blanch J, Atala J, et al. Psychiatric morbidity and impact on hospital length of stay among hematologic cancer patients receiving stem-cell transplantation. J Clin Oncol 2002; 20: 1907–1917.

    Article  PubMed  Google Scholar 

  28. Molassiotis A, Boughton BJ, Burgoyne T, et al. Comparison of the overall quality of life in 50 long-term survivors of autologous and allogeneic bone marrow transplantation. J Adv Nurs 1995; 22: 509–516.

    Article  PubMed  CAS  Google Scholar 

  29. Bush NE, Donaldson GW, Haberman MH, et al. Conditional and unconditional estimation of multidimensional quality of life after hematopoietic stem cell transplantation: a longitudinal follow-up of 415 patients. Biol Blood Marrow Transplant 2000; 6: 576–591.

    Article  PubMed  CAS  Google Scholar 

  30. Andrykowski MA, Cordova MJ, Hann DM, et al. Patients’ psychosocial concerns following stem cell transplantation. Bone Marrow Transplant 1999; 24: 1121–1129.

    Article  PubMed  CAS  Google Scholar 

  31. Meyers CA, Weitzner M, Byrne K, et al. Evaluation of the neurobehavioral functioning of patients before, during, and after bone marrow transplantation. J Clin Oncol 1994; 12: 820–826.

    PubMed  CAS  Google Scholar 

  32. Ahles TA, Tope DM, Furstenberg C, et al. Psychologic and neuropsychologic impact of autologous bone marrow transplantation. J Clin Oncol 1996; 14: 1457–1462.

    PubMed  CAS  Google Scholar 

  33. Padovan CS, Yousry TA, Schleuning M, et al. Neurological and neuroradiological findings in long-term survivors of allogeneic bone marrow transplantation. Ann Neurol 1998; 43: 627–633.

    Article  PubMed  CAS  Google Scholar 

  34. Kramer JH, Crittenden MR, DeSantes K, et al. Cognitive and adaptive behavior 1 and 3 years following bone marrow transplantation. Bone Marrow Transplant 1997; 19: 607–613.

    Article  PubMed  CAS  Google Scholar 

  35. Wingard JR, Curbow B, Baker F, et al. Sexual satisfaction in survivors of bone marrow transplantation. Bone Marrow Transplant 1992; 9: 185–190.

    PubMed  CAS  Google Scholar 

  36. Molassiotis A, van den Akker OB, Milligan DW, et al. Gonadal function and psychosexual adjustment in male long-term survivors of bone marrow transplantation. Bone Marrow Transplant 1995; 16: 253–259.

    PubMed  CAS  Google Scholar 

  37. Syrjala KL, Roth-Roemer SL, Abrams JR, et al. Prevalence and predictors of sexual dysfunction in long-term survivors of marrow transplantation. J Clin Oncol 1998; 16: 3148–157.

    PubMed  CAS  Google Scholar 

  38. Marks DI, Gale DJ, Vedhara K, et al. A quality of life study in 20 adult long-term survivors of unrelated donor bone marrow transplantation. Bone Marrow Transplant 1999; 24: 191–195.

    Article  PubMed  CAS  Google Scholar 

  39. Chiodi S, Spinelli S, Rayera G, et al. Quality of life in 244 recipients of allogeneic bone marrow transplantation. Br J Haematol 2000; 110: 614–619.

    Article  PubMed  CAS  Google Scholar 

  40. Lee SJ, Fairclough D, Parsons SK, et al. Recovery after stem-cell transplantation for hematologic diseases. J Clin Oncol 2001; 19: 242–252.

    PubMed  CAS  Google Scholar 

  41. Wingard JR, Curbow B, Baker F, et al. Health, functional status, and employment of adult survivors of bone marrow transplantation. Ann Intern Med 1991; 114: 113–118.

    PubMed  CAS  Google Scholar 

  42. Chao NJ, Tierney DK, Bloom JR, et al. Dynamic assessment of quality of life after autologous bone marrow transplantation. Blood 1992; 80: 825–830.

    PubMed  CAS  Google Scholar 

  43. Schmidt GM, Niland JC, Forman SJ, et al. Extended follow-up in 212 long-term allogeneic bone marrow transplant survivors. Issues of quality of life. Transplantation 1993; 55: 551–557.

    Article  PubMed  CAS  Google Scholar 

  44. Hjermstad MJ, Kaasa S. Quality of life in adult cancer patients treated with bone marrow transplantation a review of the literature. Eur J Cancer 1995; 2: 163–173.

    Article  Google Scholar 

  45. Andrykowski MA, Greiner CB, Altmaier EM, et al. Quality of life following bone marrow transplantation: findings from a multicentre study. Br J Cancer 1995; 71: 1322–1329.

    Article  PubMed  CAS  Google Scholar 

  46. Duell T, van Lint MT, Ljungman P, et al. Health and functional status of long-term survivors of bone marrow transplantation. EBMT Working Party on Late Effects and EULEP Study Group on Late Effects. European Group for Blood and Marrow Transplantation. Ann Intern Med 1997; 126: 184–192.

    PubMed  CAS  Google Scholar 

  47. Molassiotis A, Morris PJ. The meaning of quality of life and the effects of unrelated donor bone marrow transplants for chronic myeloid leukemia in adult long-term survivors. Cancer Nurs 1998; 21: 205–211.

    Article  PubMed  CAS  Google Scholar 

  48. Baker F, Curbow B, Wingard JR. Role retention and quality of life of bone marrow transplant survivors. Soc Sci Med 1991; 32: 697–704.

    Article  PubMed  CAS  Google Scholar 

  49. Molassiotis A, van den Akker OB, Milligan DW, et al. Quality of life in long-term survivors of marrow transplantation: comparison with a matched group receiving maintenance chemotherapy. Bone Marrow Transplant 1996; 17: 249–258.

    PubMed  CAS  Google Scholar 

  50. de Lima M, Strom SS, Keating M, et al. Implications of potential cure in acute myelogenous leukemia: development of subsequent cancer and return to work. Blood 1997; 90: 4719–4724.

    PubMed  CAS  Google Scholar 

  51. Andrykowski MA, Carpenter JS, Greiner CB, et al. Energy level and sleep quality following bone marrow transplantation. Bone Marrow Transplant 1997; 20: 669–679.

    Article  PubMed  CAS  Google Scholar 

  52. Curbow B, Somerfield MR, Baker F, et al. Personal changes, dispositional optimism, and psychological adjustment to bone marrow transplantation. J Behav Med 1993; 16: 423–443.

    Article  PubMed  CAS  Google Scholar 

  53. Fromm K, Andrykowski MA, Hunt J. Positive and negative psychosocial sequelae of bone marrow transplantation: implications for quality of life assessment. J Behav Med 1996; 19: 221–240.

    Article  PubMed  CAS  Google Scholar 

  54. Badell I, Igual L, Gomez P, et al. Quality of life in young adults having received a BMT during childhood: a GETMON study. Grupo Espanol de Trasplante de Medula Osea en el Nino. Bone Marrow Transplant 1998; 21 (suppl 2): 568–571.

    Google Scholar 

  55. Johnson Vickberg SM, Duhamel KN, Smith MY, et al. Global meaning and psychological adjustment among survivors of bone marrow transplant. Psychooncology 2001; 10: 29–39.

    Article  PubMed  CAS  Google Scholar 

  56. Ferrell BR, Hassey Dow K. Quality of life among long-term cancer survivors. Oncology (Huntingt) 1997;11:565–568, 571; discussion 572, 575–576.

    Google Scholar 

  57. Van Eys J. Living beyond cure. Transcending survival. Am J Ped Hematol/Oncol 1987; 9: 114–118.

    Article  Google Scholar 

  58. Brown HN, Kelly MJ. Stages of bone marrow transplantation: a psychiatric perspective. Psychosom Med 1976; 38: 439–446.

    PubMed  CAS  Google Scholar 

  59. Andrykowski MA, Mcquellon RP. Psychological issues in hematpoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoetic Cell Transplantation. Malden, UK: Blackwell Sciences, 1999.

    Google Scholar 

  60. Dermatis H, Lesko LM. Psychosocial correlates of physician-patient communication at time of informed consent for bone marrow transplantation. Cancer Invest 1991; 9: 621–628.

    Article  PubMed  CAS  Google Scholar 

  61. Baker F. Psychosocial sequelae of bone marrow transplantation. Oncology (Huntingt) 1994;8:87–92,97; discussion, 97–101.

    Google Scholar 

  62. Leigh S, Wilson KC, Burns R, Clark RE. Psychosocial morbidity in bone marrow transplant recipients: a prospective study. Bone Marrow Transplant 1995; 16: 635–640.

    PubMed  CAS  Google Scholar 

  63. Grassi L, Rosti G, Albertazzi L, et al. Psychological stress symptoms before and after autologous bone marrow transplantation in patients with solid tumors. Bone Marrow Transplant 1996; 17: 843–847.

    PubMed  CAS  Google Scholar 

  64. Baker F, Marcellus D, Zabora J, et al. Psychological distress among adult patients being evaluated for bone marrow transplantation. Psychosomatics 1997; 38: 10–19.

    Article  PubMed  CAS  Google Scholar 

  65. Zittoun R, Achard S, Ruszniewski M. Assessment of quality of life during intensive chemotherapy or bone marrow transplantation. Psychooncology 1999; 8: 64–73.

    Article  PubMed  CAS  Google Scholar 

  66. Prieto JM, Saez R, Carreras E, et al. Physical and psychosocial functioning of 117 survivors of bone marrow transplantation. Bone Marrow Transplant 1996; 17: 1133–1142.

    PubMed  CAS  Google Scholar 

  67. Kopp M, Schweigkofler H, Holzner B, et al. Time after bone marrow transplantation as an important variable for quality of life: results of a cross-sectional investigation using two different instruments for quality-of-life assessment. Ann Hematol 1998; 77: 27–32.

    Article  PubMed  CAS  Google Scholar 

  68. Horowitz MM. Uses and growth of hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ, eds. Hematopoetic Cell Transplantation. Malden, UK: Blackwell Sciences, 1999.

    Google Scholar 

  69. Wolcott DL, Wellisch DK, Fawzy FI, et al. Adaptation of adult bone marrow transplant recipient long-term survivors. Transplantation 1986; 41: 478–484.

    Article  PubMed  CAS  Google Scholar 

  70. Broers S, Kaptein AA, Le Cessie S, et al. Psychological functioning and quality of life following bone marrow transplantation: a 3-year follow-up study. J Psychosom Res 2000; 48: 11–21.

    Article  PubMed  CAS  Google Scholar 

  71. Andrykowski MA, Altmaier EM, Barnett RL, et al. The quality of life in adult survivors of allogeneic bone marrow transplantation. Correlates and comparison with matched renal transplant recipients. Transplantation 1990; 50: 399–406.

    Article  PubMed  CAS  Google Scholar 

  72. Molassiotis A, van den Akker OB, Boughton BJ. Perceived social support, family environment and psychosocial recovery in bone marrow transplant long-term survivors. Soc Sci Med 1997; 44: 317–325.

    Article  PubMed  CAS  Google Scholar 

  73. Heinonen H, Volin L, Uutela A, et al. Gender-associated differences in the quality of life after allogeneic BMT. Bone Marrow Transplant 2001; 28: 503–509.

    Article  PubMed  CAS  Google Scholar 

  74. Hjermstad MJ, Evensen SA, Kvaloy SO, et al. Health-related quality of life 1 year after allogeneic or autologous stem-cell transplantation: a prospective study. J Clin Oncol 1999; 17: 706–718.

    PubMed  CAS  Google Scholar 

  75. van Agthoven M, Vellenga E, Fibbe WE, et al. Cost analysis and quality of life assessment comparing patients undergoing autologous peripheral blood stem cell transplantation or autologous bone marrow transplantation for refractory or relapsed non- Hodgkin’s lymphoma or Hodgkin’s disease. a prospective randomised trial. Eur J Cancer 2001; 37: 1781–1789.

    Article  PubMed  CAS  Google Scholar 

  76. Lee SJ, Zahrieh D, Alyea EA, et al. Comparison of T-cell depled and non-T-cell depled unrelated donor transplantation for hematologic diseases: clinical outcomes, quality of life and costs. Blood 2002; 100: 2967–2702.

    Google Scholar 

  77. Colon EA, Callies AL, Popkin MK, et al. Depressed mood and other variables related to bone marrow transplantation survival in acute leukemia. Psychosomatics 1991; 32: 420–425.

    Article  PubMed  CAS  Google Scholar 

  78. Andrykowski MA, Brady MJ, Henslee-Downey PJ. Psychosocial factors predictive of survival after allogeneic bone marrow transplantation for leukemia. Psychosom Med 1994; 56: 432–439.

    PubMed  CAS  Google Scholar 

  79. Murphy DJ, Burrows D, Santilli S, et al. The influence of the probability of survival on patients’ preferences regarding cardiopulmonary resuscitation [see comments]. N Engl J Med 1994; 330: 545–549.

    Article  PubMed  CAS  Google Scholar 

  80. Jenkins PL, Lester H, Alexander J, Whittaker J. A prospective study of psychosocial morbidity in adult bone marrow transplant recipients. Psychosomatics 1994; 35: 361–367.

    Article  PubMed  CAS  Google Scholar 

  81. Loberiza FR Jr, Rizzo JD, Bredeson CN, et al. Association of depressive syndrome and early deaths among patients after stem-cell transplantation for malignant diseases. J Clin Oncol 2002; 20: 2118–2126.

    Article  PubMed  Google Scholar 

  82. Futterman AD, Wellisch DK, Bond G, et al. The Psychosocial Levels System. A new rating scale to identify and assess emotional difficulties during bone marrow transplantation. Psychosomatics 1991; 32: 177–186.

    Article  PubMed  CAS  Google Scholar 

  83. Twillman RK, Manetto C, Wellisch DK, et al. The Transplant Evaluation Rating Scale. A revision of the psychosocial levels system for evaluating organ transplant candidates. Psychosomatics 1993; 34: 144–153.

    Article  PubMed  CAS  Google Scholar 

  84. Presberg BA, Levenson IL, Olbrisch ME, Best AM. Rating scales for the psychosocial evaluation of organ transplant candidates. Comparison of the PACT and TERS with bone marrow transplant patients. Psychosomatics 1995; 36: 458–461.

    Article  PubMed  CAS  Google Scholar 

  85. Molassiotis A. Further evaluation of a scale to screen for risk of emotional difficulties in bone marrow transplant recipients. J Adv Nurs 1999; 29: 922–927.

    Article  PubMed  CAS  Google Scholar 

  86. Sullivan AK, Szkrumelak N, Hoffman LH. Psychological risk factors and early complications after bone marrow transplantation in adults. Bone Marrow Transplant 1999; 24: 1109–1120.

    Article  PubMed  CAS  Google Scholar 

  87. Litwins NM, Rodrigue JR, Weiner RS. Quality of life in adult recipients of bone marrow transplantation. Psychol Rep 1994; 75: 323–328.

    Article  PubMed  CAS  Google Scholar 

  88. Wellisch DK, Centeno J, Guzman J, et al. Bone marrow transplantation vs. high-dose cytorabine-based consolidation chemotherapy for acute myelogenous leukemia. A long-term follow-up study of quality-of-life measures of survivors. Psychosomatics 1996; 37: 144–154.

    Article  PubMed  CAS  Google Scholar 

  89. Hjermstad MJ, Loge JH, Evensen SA, et al. The course of anxiety and depression during the first year after allogeneic or autologous stem cell transplantation. Bone Marrow Transplant 1999; 24: 1219–1228.

    Article  PubMed  CAS  Google Scholar 

  90. Slevin ML, Stubbs L, Plant HJ, et al. Attitudes to chemotherapy: comparing views of patients with cancer with those of doctors, nurses, and general public [see comments]. Br Med J 1990; 300: 1458–1460.

    Article  CAS  Google Scholar 

  91. Yellen SB, Cella DF, Leslie WT. Age and clinical decision making in oncology patients [see comments]. J Natl Cancer Inst 1994; 86: 1766–1770.

    Article  PubMed  CAS  Google Scholar 

  92. Yellen SB, Cella DF. Someone to live for: social well-being, parenthood status, and decision-making in oncology. J Clin Oncol 1995; 13: 1255–1264.

    PubMed  CAS  Google Scholar 

  93. McQuellon RP, Muss HB, Hoffman SL, et al. Patient preferences for treatment of metastatic breast cancer: a study of women with early-stage breast cancer. J Clin Oncol 1995; 13: 858–868.

    PubMed  CAS  Google Scholar 

  94. Singer DA, Donnelly MB, Messerschmidt GL. Informed consent for bone marrow transplantation: identification of relevant information by referring physicians. Bone Marrow Transplant 1990; 6: 431–437.

    PubMed  CAS  Google Scholar 

  95. Jacoby LH, Maloy B, Cirenza E, et al. The basis of informed consent for BMT patients. Bone Marrow Transplant 1999; 23: 711–717.

    Article  PubMed  CAS  Google Scholar 

  96. Whedon M, Ferrell BR. Quality of life in adult bone marrow transplant patients: beyond the first year. Semin Oncol Nurs 1994; 10: 42–57.

    Article  PubMed  CAS  Google Scholar 

  97. Lesko LM, Dermatis H, Penman D, et al. Patients’, parents’, and oncologists’ perceptions of informed consent for bone marrow transplantation. Med Pediatr Oncol 1989; 17: 181–187.

    Article  PubMed  CAS  Google Scholar 

  98. Perry D. Psychological and social preparation for bone marrow transplantation. Soc Work Health Care 2000; 30: 71–92.

    Article  PubMed  CAS  Google Scholar 

  99. Dimeo F, Bertz H, Finke J, et al. An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant 1996; 18: 1157–1160.

    PubMed  CAS  Google Scholar 

  100. Dimeo F, Fetscher S, Lange W, et al. Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 1997; 90: 3390–3394.

    PubMed  CAS  Google Scholar 

  101. Dimeo FC, Stieglitz RD, Novelli-Fischer U, et al. Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer 1999; 85: 2273–2277.

    Article  PubMed  CAS  Google Scholar 

  102. Gaston-Johansson F, Fall-Dickson JM, Nanda J, et al. The effectiveness of the comprehensive coping strategy program on clinical outcomes in breast cancer autologous bone marrow transplantation. Cancer Nurs 2000; 23: 277–285.

    Article  PubMed  CAS  Google Scholar 

  103. Syrjala KL, Donaldson GW, Davis MW, et al. Relaxation and imagery and cognitive-behavioral training reduce pain during cancer treatment: a controlled clinical trial. Pain 1995; 63: 189–198.

    Article  PubMed  CAS  Google Scholar 

  104. Matthes-Martin S, Lamche M, Ladenstein R, et al. Organ toxicity and quality of life after allogeneic bone marrow transplantation in pediatric patients: a single centre retrospective analysis. Bone Marrow Transplant 1999; 23: 1049–1053.

    Article  PubMed  CAS  Google Scholar 

  105. Dermatis H, Lesko LM. Psychological distress in parents consenting to child’s bone marrow transplantation. Bone Marrow Transplant 1990; 6: 411–417.

    PubMed  CAS  Google Scholar 

  106. Keogh F, O’ Riordan J, McNamara C, et al. Psychosocial adaptation of patients and families following bone marrow transplantation: a prospective, longitudinal study. Bone Marrow Transplant 1998; 22: 905–911.

    Article  PubMed  CAS  Google Scholar 

  107. Buckner CD, Clift RA, Sanders JE, et al. Marrow harvesting from normal donors. Blood 1984; 64: 630–634.

    PubMed  CAS  Google Scholar 

  108. Chang G, McGarigle C, Spitzer TR, et al. A comparison of related and unrelated marrow donors. Psychosom Med 1998; 60: 163–167.

    PubMed  CAS  Google Scholar 

  109. Chern B, McCarthy N, Hutchins C, et al. Analgesic infiltration at the site of bone marrow harvest significantly reduces donor morbidity. Bone Marrow Transplant 1999; 23: 947–949.

    Article  PubMed  CAS  Google Scholar 

  110. Butterworth VA, Simmons RG, Bartsch G, et al. Psychosocial effects of unrelated bone marrow donation: experiences of the National Marrow Donor Program. Blood 1993; 81: 1947–1959.

    PubMed  CAS  Google Scholar 

  111. Stroncek DF, Holland PV, Bartch G, et al. Experiences of the first493 unrelated marrow donors in the National Marrow Donor Program. Blood 1993; 81: 1940–1946.

    PubMed  CAS  Google Scholar 

  112. Simmons RG, Schimmel M, Butterworth VA. The self-image of unrelated bone marrow donors. J Health Soc Behav 1993; 34: 285–301.

    Article  PubMed  CAS  Google Scholar 

  113. Nishimori M, Yamada Y, Hoshi K, et al. Health-related quality of life of unrelated bone marrow donors in Japan. Blood 2002; 99: 1995–2001.

    Article  PubMed  CAS  Google Scholar 

  114. Sloan JA, Cella D, Frost M, et al. Assessing clinical significance in measuring oncology patient quality of life: introduction to the symposium, content overview, and definition of terms. Mayo Clin Proc 2002; 77: 367–370.

    Article  PubMed  Google Scholar 

  115. Litwin MS, McGuigan KA. Accuracy of recall in health-related quality-of-life assessment among men treated for prostate cancer. J Clin Oncol 1999; 17: 2882–2888.

    PubMed  CAS  Google Scholar 

  116. Schluchter MD. Methods for the analysis of informatively censored longitudinal data. Stat Med 1992; 11: 1861–1870.

    Article  PubMed  CAS  Google Scholar 

  117. Fairclough DL, Hwang S, Chang V. Health related quality of life in terminal cancer patients: unbiased estimation in longitudinal studies with missing data due to morbidity and mortality. Boston: Dana-Farber Cancer Institute, 1996.

    Google Scholar 

  118. Andrykowski MA, Bruehl S, Brady MJ, et al. Physical and psychosocial status of adults one-year after bone marrow transplantation: a prospective study. Bone Marrow Transplant 1995; 15: 837–844.

    PubMed  CAS  Google Scholar 

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  1. Stephanie J. Lee MD MPH
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  1. Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA

    Robert J. Soiffer MD

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Lee, S.J. (2004). Quality-of-Life Issues Posttransplantation. In: Soiffer, R.J. (eds) Stem Cell Transplantation for Hematologic Malignancies. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-733-8_14

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