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Stem Cell Transplantation for Hematologic Malignancies

  • Robert J. Soiffer

Part of the Contemporary Hematology book series (CH)

Table of contents

  1. Front Matter
    Pages i-x
  2. Transplant for Malignant Disease

    1. Front Matter
      Pages 1-1
    2. Thomas J. Kenney, John W. Sweetenham
      Pages 47-84
    3. Faith E. Davies, Kenneth C. Anderson
      Pages 85-97
    4. Yago Nieto, Elizabeth J. Shpall
      Pages 99-132
  3. Complications of Transplantion

    1. Front Matter
      Pages 133-133
    2. Takanori Teshima, James L. M. Ferrara
      Pages 135-157
    3. Uwe Platzbecker, H. Joachim Deeg
      Pages 159-184
    4. Georgia B. Vogelsang, Colleen H. McDonough
      Pages 185-200
    5. Carolyn A. Keever-Taylor
      Pages 201-236
    6. Lindsey Baden, Robert H. Rubin
      Pages 237-258
    7. Stephen Gottschalk, Cliona M. Rooney, Helen E. Heslop
      Pages 259-270
    8. Paul G. Richardson
      Pages 297-314
    9. Stephanie J. Lee
      Pages 315-333
  4. Sources of Donor Stem Cells

    1. Front Matter
      Pages 335-335
    2. Corey Cutler, Joseph H. Antin
      Pages 337-356
    3. P. Jean Henslee-Downey
      Pages 373-389
    4. Timothy F. Goggins, Nelson J. Chao
      Pages 391-414
  5. Graft Engineering

    1. Front Matter
      Pages 415-415
    2. John G. Gribben
      Pages 417-429
    3. Vincent Ho, Robert J. Soiffer
      Pages 431-451
  6. Graft-Vs-Tumor Effect

    1. Front Matter
      Pages 451-451
    2. Edwin P. Alyea III
      Pages 453-469
    3. Lyle C. Feinstein, Brenda M. Sandmaier
      Pages 469-484
  7. Back Matter
    Pages 485-486

About this book

Introduction

Over the past several years, fundamental notions about transplantation have changed to such a degree that even the once familiar term, bone marrow transplant, is becoming increasingly outdated. In Stem Cell Transplantation for Hematologic Malignancies, leading investigators and physicians/clinicans comprehensively survey the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic graft-vs-host disease (GVHD), delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation. Also discussed are the role of donor lymphocyte infusions in the treatment and prevention of relapse after stem cell transplantation and their influence on the development of nonmyeloablative transplantation.
Comprehensive and state-of-the-art, Stem Cell Transplantation for Hematologic Malignancies outlines the many exciting advances that are working toward realization today while fully explaining the process of stem cell transplantation for malignant disease.

Keywords

blood bone marrow cell hematopoietic stem cell hematopoietic stem cell transplantation leukemia liver lymphocytes lymphoma stem cell stem cell transplantation stem cells transplantation tumor

Editors and affiliations

  • Robert J. Soiffer
    • 1
  1. 1.Division of Hematologic Malignancies, Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA

Bibliographic information

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