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Targeting the TGF-β Pathway In Vivo

Defining Complex Roles for TGF-β Signaling in Immune Function, Wound Healing, and Carcinogenesis

  • Chapter
Cytokine Knockouts

Part of the book series: Contemporary Immunology ((CONTIM))

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Abstract

Transforming growth factor-ß1 (TGF-(ß1) is a 25-kDa homodimeric peptide and the prototype in a family of structurally related but functionally distinct regulatory proteins. These TGF-ß isoforms (TGF-ß1, -ß2, and -ß3 in mammals) bear some structural relationship to a much larger family of peptide signaling molecules, with over 45 known members in this superfamily. The high degree of similarity that exists at the structural level among the isoforms of these growth factors is also accompanied by a significant overlap in function, as defined by many in vitro model systems. Moreover, the signaling pathway is not strictly linear in that there is extensive crosstalk with components of other signaling cascades (Fig. 1), with the TGF-ßs typically influencing the manner in which cells interpret other signals in their environment. The evolution of more sophisticated functional genomics approaches has been instrumental in generating unique perspectives into the mechanisms governing the activity of the members of the TGF-ß family. The studies outlined in this review serve to demonstrate how these models are more clearly defining the function of this pathway in immune homeostasis, wound healing, and carcinogenesis.

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Authors
  1. Lawrence Wolfraim
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  2. Mizuko Mamura
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  3. Anita Roberts
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  4. John J. Letterio
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Editors and Affiliations

  1. University of Colorado Health Sciences Center, Denver, CO, USA

    Giamila Fantuzzi PhD

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Wolfraim, L., Mamura, M., Roberts, A., Letterio, J.J. (2003). Targeting the TGF-β Pathway In Vivo. In: Fantuzzi, G. (eds) Cytokine Knockouts. Contemporary Immunology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-405-4_24

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  • DOI: https://doi.org/10.1007/978-1-59259-405-4_24

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