Diabetes and Thrombosis

  • David J. Schneider
  • Burton E. Sobel
Part of the Contemporary Cardiology book series (CONCARD)


Complications of macrovascular disease, referred to by some as atherothrombosis, are responsible for 50% of the deaths in patients with type 2 diabetes mellitus, 27% of the deaths in patients with type 1 diabetes for 35 years or less, and 67% of the deaths in patients with type 1 diabetes for 40 years or more (1,2). The rapid progression of macroangiopathy in patients with type 2 diabetes may reflect diverse phenomena: some intrinsic to the vessel wall; angiopathic factors such as elevated homocysteine and hyperlipidemia; deleterious effects of dysinsulinemia; and excessive or persistent microthrombi with consequent acceleration of vasculopathy secondary to clot-associated mitogens (3,4). As a result of their adverse effects, cardiovascular mortality is as high as 15% in the 10 years after the diagnosis of diabetes mellitus becomes established (5). Because more than 90% of patients with diabetes have type 2 diabetes and because macrovascular disease is the cause of death in most patients with type 2 as opposed to type 1 (insulinopenic) diabetes, type 2 diabetes will be the focus of our discussion.


Plasminogen Activator Plaque Rupture Plasminogen Activator Inhibitor Type Fibrinolytic System Macrovascular Disease 
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • David J. Schneider
  • Burton E. Sobel

There are no affiliations available

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