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Diabetes and Thrombosis

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Diabetes and Cardiovascular Disease

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Complications of macrovascular disease, referred to by some as atherothrombosis, are responsible for 50% of the deaths in patients with type 2 diabetes mellitus, 27% of the deaths in patients with type 1 diabetes for 35 years or less, and 67% of the deaths in patients with type 1 diabetes for 40 years or more (1,2). The rapid progression of macroangiopathy in patients with type 2 diabetes may reflect diverse phenomena: some intrinsic to the vessel wall; angiopathic factors such as elevated homocysteine and hyperlipidemia; deleterious effects of dysinsulinemia; and excessive or persistent microthrombi with consequent acceleration of vasculopathy secondary to clot-associated mitogens (3,4). As a result of their adverse effects, cardiovascular mortality is as high as 15% in the 10 years after the diagnosis of diabetes mellitus becomes established (5). Because more than 90% of patients with diabetes have type 2 diabetes and because macrovascular disease is the cause of death in most patients with type 2 as opposed to type 1 (insulinopenic) diabetes, type 2 diabetes will be the focus of our discussion.

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Authors
  1. David J. Schneider MD
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  2. Burton E. Sobel MD
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Editor information

Editors and Affiliations

  1. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Michael T. Johnstone MD, CM, FRCP(C)  & Aristidis Veves MD, DSC  & 

  2. Harvard Medical School, Boston, MA, USA

    Michael T. Johnstone MD, CM, FRCP(C)  & Aristidis Veves MD, DSC  & 

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© 2001 Springer Science+Business Media New York

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Schneider, D.J., Sobel, B.E. (2001). Diabetes and Thrombosis. In: Johnstone, M.T., Veves, A. (eds) Diabetes and Cardiovascular Disease. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-091-9_9

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  • DOI: https://doi.org/10.1007/978-1-59259-091-9_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4962-5

  • Online ISBN: 978-1-59259-091-9

  • eBook Packages: Springer Book Archive

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