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The Central Nervous System as a Direct Target for Growth Hormone Action

  • Chapter
Human Growth Hormone

Part of the book series: Contemporary Endocrinology ((COE,volume 19))

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Abstract

To stimulate postnatal body growth in a coordinated fashion, growth hormone (GH) acts directly or indirectly on virtually every tissue in the body. Furthermore, GH has metabolic actions that are important in many species long after major statural growth has been accomplished. Although the actions of GH were long thought to be mediated entirely via the generation of hepatic insulin-like growth factor-1 (IGF-1), it is now clear that GH also has direct effects in many tissues acting in concert with locally generated IGF-1 (and probably many other growth factors) in addition to IGF-1 from the circulation. Although the brain is not usually considered an obvious target tissue for GH there is increasing circumstantial and direct evidence to support this idea. In this short chapter the authors address three principle questions:

  1. 1.

    Are there specific functional receptors for GH in the central nervous system (CNS)?

  2. 2.

    How does GH reach these receptors in adequate amounts? and

  3. 3.

    Do these receptors mediate physiological effects of GH within the CNS?

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Authors
  1. Pamela A. Bennett BSc DPhil
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  2. Iain C. A. F. Robinson MA DPhil
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Editors and Affiliations

  1. Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA

    Roy G. Smith PhD

  2. Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, VA, USA

    Michael O. Thorner MD

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© 2000 Humana Press Inc., Totowa, NJ

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Bennett, P.A., Robinson, I.C.A.F. (2000). The Central Nervous System as a Direct Target for Growth Hormone Action. In: Smith, R.G., Thorner, M.O. (eds) Human Growth Hormone. Contemporary Endocrinology, vol 19. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-015-5_10

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  • DOI: https://doi.org/10.1007/978-1-59259-015-5_10

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9610-9

  • Online ISBN: 978-1-59259-015-5

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