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Human Growth Hormone

Research and Clinical Practice

  • Book
  • © 2000

Overview

Editors:
  1. Roy G. Smith

    1. Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Michael O. Thorner

    1. Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary Endocrinology (COE, volume 19)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
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  2. Overview of Human Growth Hormone

    1. Overview of Human Growth Hormone

      • Roy G. Smith
      Pages 1-13

  3. Research

    1. Front Matter

      Pages 15-15
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    2. GHRP Historical Perspective

      • C. Y. Bowers
      Pages 17-43

    3. The Design of Peptidomimetic Growth Hormone Secretagogues

      • Arthur A. Patchett, Matthew J. Wyvratt
      Pages 45-67

    4. Molecular Characterization of Growth Hormone Secretagogue Receptors

      • Andrew D. Howard, Scott D. Feighner, Roy G. Smith, Lex H. T. Van der Ploeg
      Pages 69-84

    5. Central Actions of Peptide and Nonpeptide Growth Hormone Secretagogues

      • Suzanne L. Dickson, Gareth Leng
      Pages 85-95

    6. Pharmacology of Growth Hormone-Releasing Hormone and Its Peptide Analogs

      • David H. Coy
      Pages 97-108

    7. Somatostatin Receptor Subtypes and Regulation of GH Secretion

      • Gurkeerat Singh, George Liapakis, Terry Reisine
      Pages 109-117

    8. Mathematical Modeling of the GH Release Axis

      • David Brown, Elinor A. Stephens, Gareth Leng, Roy G. Smith
      Pages 119-130

    9. Activation of the Human Growth Hormone Receptor

      • Kenneth H. Pearce, James A. Wells
      Pages 131-143

    10. The Central Nervous System as a Direct Target for Growth Hormone Action

      • Pamela A. Bennett, Iain C. A. F. Robinson
      Pages 145-166

  4. Clinical Practice

    1. Front Matter

      Pages 167-167
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    2. Molecular Defects of the Growth Hormone Axis

      • Linda Anne DiMeglio, Paul L. Hofman, Ora Hirsch Pescovitz
      Pages 169-190

    3. Growth Hormone

      • Barry B. Bercu, Howard J. Heinze
      Pages 191-219

    4. Growth Hormone Deficiency in Adults

      • Paul V. Carroll, Emanuel R. Christ, Peter H. Sönksen
      Pages 221-232

    5. Growth Hormone and Osteoporosis

      • Howard B. A. Baum, Anne Klibanski
      Pages 233-245

    6. Growth Hormone and Syndrome X

      • Gudmundur Johannsson, Per Mårin, Jan-Ove Johansson, Bengt Åke Bengtsson
      Pages 247-260

    7. Interactions Between Growth Hormone Secretion and Sleep

      • Eve Van Cauter, Georges Copinschi
      Pages 261-283

    8. Growth Hormone in AIDS

      • Kathleen Mulligan, Morris Schambelan
      Pages 285-295
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Keywords

About this book

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.

Reviews

"This book is designed as a summary of the basic and clinical aspects of the regulation of GH axis as well as the effects of GH in catabolic conditions and GH deficiency. . .Particularly good are the basic chapters on the design of GH secretagogues, structure and function of GH receptor, and the CNS effects of GH. The chapter on interrelations between GH secretion and sleep is superb in that it is a brief but comprehensive treatment of the topic. . . This is a good summary of some novel aspects of basic GH research."-Doody's Health Science Book Review Journal

"A concise, well written, amply illustrated and referenced text." -Journal of Pediatric Endocrinology & Metabolism

"Human Growth Hormones: Research and Clinical Practice fulfills every expectation of excellence, largely as a result of the outstanding caliber of the contributors....the volume blends the basic-science elements of secretagogue discovery with the investigative clinical applications of GHRHs and GHRPs in the thorough and thoughtful manner....Central nervous system (CNS) actions of GHRH and GHRP agonists are presented in two outstanding chapters, followed b a brief but comprehensible biomathematical model of agonist-receptor-driven GH secretion as modulated by somatostatin restraint. The overview of pediatric neuroendocrinology by Bercu et al. is comprehensive and articulate....The illustrations throughout the text are plentiful and superb....As a clinical neuroendocrinologist working in the arena of GH pathophysiology, and teaching at the basic fellowship level, I regard this as one of the bright stars among scholarly updates for clinicians, research fellows and senior scientists"-Trends in Endocrinology and Metabolism

Editors and Affiliations

  • Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, USA

    Roy G. Smith

  • Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA

    Michael O. Thorner

Bibliographic Information

  • Book Title: Human Growth Hormone

  • Book Subtitle: Research and Clinical Practice

  • Editors: Roy G. Smith, Michael O. Thorner

  • Series Title: Contemporary Endocrinology

  • DOI: https://doi.org/10.1007/978-1-59259-015-5

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-89603-505-8Published: 28 January 2000

  • Softcover ISBN: 978-1-4684-9610-9Published: 31 July 2012

  • eBook ISBN: 978-1-59259-015-5Published: 28 January 2000

  • Series ISSN: 2523-3785

  • Series E-ISSN: 2523-3793

  • Edition Number: 1

  • Number of Pages: X, 348

  • Topics: Endocrinology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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