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Mitochondrial Signaling

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Mitochondria and Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

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Abstract

Mitochondria constantly communicate with the rest of the cell. Nuclear gene expression programs regulating the expression of mitochondrial constituents adapt the mitochondrial network to the needs of the cells (anterograde signaling). Reciprocally, mitochondria inform the cytoplasm on its requirements, so that the cell can trigger the necessary adaptive responses (retrograde signaling).

Different types of mitochondrial stress have been shown to trigger many cytoplasmic signaling pathways, and the nature of the signals that are exported from mitochondria and affect the cellular signaling environment remains an area of intensive research.

This chapter explores a conceptual framework for mitochondrial signaling, discussing the characteristics that constitute a mitochondrial signal, as well as the different types of mitochondrial signals currently known. Furthermore, the communication between mitochondria and the rest of the cell is put in a context that includes other cellular components, since in order to understand how cells respond to mitochondrial stress, it is necessary to understand what components of that response come from secondary responses in other organelles.

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Authors and Affiliations

  1. Institute for Cellular Biochemistry, Universitätsmedizin Göttingen, Humboldtallee 23, Room 01.423, 37073, Göttingen, Germany

    Nuno Raimundo, Lorena Fernandez-Mosquera & King Faisal Yambire

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  1. Nuno Raimundo
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  2. Lorena Fernandez-Mosquera
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  3. King Faisal Yambire
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Correspondence to Nuno Raimundo .

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  1. Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    David M. Hockenbery

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Raimundo, N., Fernandez-Mosquera, L., Yambire, K.F. (2016). Mitochondrial Signaling. In: Hockenbery, D. (eds) Mitochondria and Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3612-0_9

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