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Bcl-2 Protein Interplay on the Outer Mitochondrial Membrane

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Mitochondria and Cell Death

Part of the book series: Cell Death in Biology and Diseases ((CELLDEATH))

Abstract

Members of the B-cell lymphoma-2 (Bcl-2) protein family control the intrinsic pathway of regulated cell death. Pro-apoptotic and pro-survival proteins of this protein family form a complex regulatory network that mediates a variety of cellular stresses. Activation of either pro-apoptotic Bax or Bak commits the cell to apoptosis by permeabilization of the outer mitochondrial membrane. Despite extensive research on the mechanisms of Bax/Bak activation, insights into the nature of the active forms of Bax or Bak and the processes leading to their activation are incomplete.

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Authors and Affiliations

  1. Institute for Biochemistry and Molecular Biology, University of Freiburg, Stefan-Meier-Str.17, Freiburg, 79104, Germany

    Frank Edlich

  2. BIOSS, Centre for Biological Signaling Studies, University of Freiburg, Freiburg, 79104, Germany

    Frank Edlich

  3. Department of Cell Biology, University of Geneva, 30 quai Ernest-Ansermet, 1211, Genève 4, Switzerland

    Jean-Claude Martinou

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  1. Frank Edlich
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  2. Jean-Claude Martinou
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Correspondence to Frank Edlich .

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  1. Clinical Research Divison, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

    David M. Hockenbery

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Edlich, F., Martinou, JC. (2016). Bcl-2 Protein Interplay on the Outer Mitochondrial Membrane. In: Hockenbery, D. (eds) Mitochondria and Cell Death. Cell Death in Biology and Diseases. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3612-0_4

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